Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality.
Olfactory receptor neurons generate multiple response motifs, increasing coding space dimensionality.
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DOI：
10.7554/elife.79152
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发表时间：
2023-01-31
期刊：
影响因子：
7.7
通讯作者：
Stopfer MA
中科院分区：
文献类型：
--
作者：
Kim B;Haney S;Milan AP;Joshi S;Aldworth Z;Rulkov N;Kim AT;Bazhenov M;Stopfer MA
与嗅觉受体神经元（ORN）结合的气味剂会触发动作电位的爆发，为大脑提供其唯一的嗅觉环境体验。我们对蝗虫 ORN 进行的体内记录表明，气味引发的放电模式包含四种不同的反应模式，每种反应模式都由可靠的时间曲线定义。不同的气味剂可以从给定的 ORN 中引发不同的响应基序，我们将这种特性称为基序转换。此外，当被重复的羽毛状气味脉冲激活时，每个图案都会经历自己形式的感官适应。受我们的记录限制的计算模型表明，将响应组织成多个主题为气味分类和处理复杂的气味羽流提供了巨大的好处：每个主题对编码羽流的组成和结构都有独特的贡献。多个主题和主题切换通过扩展编码维度进一步改善气味分类。我们的模型证明，这些响应特征可以为嗅觉导航提供好处，包括确定到气味源的距离。
Odorants binding to olfactory receptor neurons (ORNs) trigger bursts of action potentials, providing the brain with its only experience of the olfactory environment. Our recordings made in vivo from locust ORNs showed that odor-elicited firing patterns comprise four distinct response motifs, each defined by a reliable temporal profile. Different odorants could elicit different response motifs from a given ORN, a property we term motif switching. Further, each motif undergoes its own form of sensory adaptation when activated by repeated plume-like odor pulses. A computational model constrained by our recordings revealed that organizing responses into multiple motifs provides substantial benefits for classifying odors and processing complex odor plumes: each motif contributes uniquely to encode the plume’s composition and structure. Multiple motifs and motif switching further improve odor classification by expanding coding dimensionality. Our model demonstrated that these response features could provide benefits for olfactory navigation, including determining the distance to an odor source.
影响因子：
3.7
作者：
Bobkov Y;Park I;Ukhanov K;Principe J;Ache B
通讯作者：
Ache B
影响因子：
4.3
作者：
Levakova M;Kostal L;Monsempès C;Jacob V;Lucas P
通讯作者：
Lucas P