Crosstalk Between Adipose Tissue and the Heart: An Update.

Crosstalk Between Adipose Tissue and the Heart: An Update.
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DOI:
10.2478/jtim-2022-0039
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发表时间:
2022-09
影响因子:
4.9
通讯作者:
Scherer, Philipp E.
Scherer, Philipp E.
中科院分区:
医学3区
文献类型:
--
作者:
Li, Chao;Sun, Xue-Nan;Zhao, Shangang;Scherer, Philipp E.

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重要的是要了解不同的人体器官如何相互协调和相互作用。由于肥胖和心脏疾病经常同时发生,脂肪组织和心脏之间的串扰引起了人们的关注。我们认识到特定的肽/蛋白质、脂质、核酸甚至细胞器在脂肪组织和心脏之间穿梭。这些生物活性成分可以深刻地影响包括心脏在内的远端器官中细胞的代谢。重要的是,这一过程可以在病理生理条件下失调。这也为靶向这些介质作为治疗糖尿病和心血管疾病患者的潜在治疗策略的努力打开了大门。在这里,我们总结了最近的进展,以更好地了解如何脂肪组织和心脏相互作用。
It is important to understand how different human organs coordinate and interact with each other. Since obesity and cardiac disease frequently coincide, the crosstalk between adipose tissues and heart has drawn attention. We appreciate that specific peptides/proteins, lipids, nucleic acids, and even organelles shuttle between the adipose tissues and heart. These bioactive components can profoundly affect the metabolism of cells in distal organs, including heart. Importantly, this process can be dysregulated under pathophysiological conditions. This also opens the door to efforts targeting these mediators as potential therapeutic strategies to treat patients who manifest diabetes and cardiovascular disease. Here, we summarize the recent progress toward a better understanding of how the adipose tissues and heart interact with each other.
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