Regulation of microRNA processing in development, differentiation and cancer.
Regulation of microRNA processing in development, differentiation and cancer.
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DOI：
10.1111/j.1582-4934.2008.00483.x
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发表时间：
2008-10
影响因子：
5.3
通讯作者：
Schmittgen TD
中科院分区：
文献类型：
--
作者：
Schmittgen TD
微小RNA（miRNA）是一类小型、非编码、调节性RNA。在一系列协调的事件之后，从较大的前体分子加工出2021 nt成熟miRNA。理论上，miRNA加工可以在这些步骤中的任何一个进行调节。越来越多的证据已经证明了在miRNA生物合成过程中发生调节的各个步骤。miRNA前体的RNA编辑、miRNA前体中的SNP或突变、RNA结合蛋白的调节、关键加工蛋白水平的改变以及许多未知机制有助于miRNA加工的调节。本文综述了有关正常细胞内、发育过程中或癌症等疾病中miRNA加工调控的文献。
microRNA (miRNA) is a class of small, noncoding, regulatory RNAs. The ∼ 21 nt mature miRNA is processed from larger precursor molecules following a coordinated series of events. In theory, miRNA processing may be regulated at any of these steps. A growing body of evidence has demonstrated various steps in the miRNA biogenesis process for which regulation occurs. RNA editing of miRNA precursors, SNPs or mutations in the miRNA precursors, regulation by RNA binding proteins, alterations in the levels of key processing proteins, as well as a number of unknown mechanisms contribute to the regulation of miRNA processing. This article reviews the available literature on the regulation of miRNA processing that occurs within normal cells, during development or in diseases such as cancer.
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影响因子：
14.9
作者：
Chen C;Ridzon DA;Broomer AJ;Zhou Z;Lee DH;Nguyen JT;Barbisin M;Xu NL;Mahuvakar VR;Andersen MR;Lao KQ;Livak KJ;Guegler KJ
通讯作者：
Guegler KJ
影响因子：
11.2
作者：
Gramantieri, Laura;Ferracin, Manuela;Negrini, Massimo
通讯作者：
Negrini, Massimo
影响因子：
3.5
作者：
Chiosea, S. I.;Barnes, E. L.;Seethala, R. R.
通讯作者：
Seethala, R. R.
影响因子：
64.5
作者：
Han, Jinju;Lee, Yoontae;Kim, V. Narry
通讯作者：
Kim, V. Narry
影响因子：
3.5
作者：
Duan, Ranhui;Pak, ChangHui;Jin, Peng
通讯作者：
Jin, Peng