Myocardial extracellular volume fraction from T1 measurements in healthy volunteers and mice: relationship to aging and cardiac dimensions.
Myocardial extracellular volume fraction from T1 measurements in healthy volunteers and mice: relationship to aging and cardiac dimensions.
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健康志愿者和小鼠的T1测量值的心肌外体积分数：与衰老和心脏维度的关系。
DOI：
10.1016/j.jcmg.2012.09.020
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发表时间：
2013-06
影响因子：
14
通讯作者：
Jerosch-Herold, Michael
中科院分区：
文献类型：
--
作者：
Neilan, Tomas G.;Coelho-Filho, Otavio R.;Shah, Ravi V.;Abbasi, Siddique A.;Heydari, Bobak;Watanabe, Eri;Chen, Yucheng;Mandry, Damien;Pierre-Mongeon, Francois;Blankstein, Ron;Kwong, Raymond Y.;Jerosch-Herold, Michael
我们的目的是测试健康志愿者的心肌细胞外容积（ECV）分数的特性，来自于对比前后的T1测量。对比前后心肌和血液的心脏磁共振（CMR）T1测量值允许量化ECV，ECV是一种已显示与结缔组织分数成比例变化的组织参数。健康志愿者接受了钆给药的标准CMR。T1测量采用Look-Echo序列，然后进行梯度回波采集。我们测试了ECV的节段、切片间、间、内和重测特征，以及ECV与其他变量的关联。幼年和老年小鼠经历类似的方案，收获心脏切片用于测量纤维化。在健康志愿者（n=32，56%女性;年龄21 - 72）中，ECV平均为0.28 ± 0.03（范围0.23 - 0.33）。ECV的观察者内、观察者间和重测绝对一致性的组内系数分别为0.94（95%置信区间，0.84 - 0.98）、0.93（95%置信区间，0.80 - 0.98）和0.95（95%置信区间，0.52 - 0.99）。在志愿者中，ECV与年龄（r=0.74，p< 0.001）、最大LA容积指数（r=0.67，p< 0.001）和LV质量指数相关。切片中的节段之间或切片之间的ECV没有差异。在小鼠（n=12）中，心肌ECV范围为0.20至0.32，并随年龄增加（0.22 ± 0.02 vs. 0.30 ± 0.02，幼年小鼠vs.老年小鼠，p< 0.001）。在小鼠中，ECV与心肌纤维化程度相关（r=0.94，p< 0.001）。在健康志愿者中，心肌ECV范围为0.23至0.33，具有可接受的测试特征，并与年龄、LA体积和LV质量相关。在小鼠中，ECV也随着年龄的增长而增加，并与心肌纤维化的程度密切相关。
We aimed to test the characteristics of the myocardial extracellular volume (ECV) fraction derived from pre and post-contrast T1 measurements among healthy volunteers. Cardiac magnetic resonance (CMR) T1 measurements of myocardium and blood before and after contrast allow quantification of the ECV, a tissue parameter that has been shown to change in proportion to the connective tissue fraction. Healthy volunteers underwent a standard CMR with administration of gadolinium. T1 measurements were performed with a Look-Locker sequence followed by gradient-echo acquisition. We tested the segmental, inter-slice, inter-, intra-, and test-retest characteristics of the ECV, as well as the association of the ECV with other variables. Juvenile and aged mice underwent a similar protocol and cardiac sections were harvested for measurement of fibrosis. In healthy volunteers (n=32, 56% female; ages 21 to 72), the ECV averaged 0.28 ± 0.03 (range 0.23 to 0.33). The intra-class coefficients for the intra-observer, inter-observer, and test-retest absolute agreements of the ECV were 0.94 (95% confidence interval, 0.84 to 0.98), 0.93 (95% confidence interval, 0.80 to 0.98), and 0.95 (95% confidence interval, 0.52 to 0.99), respectively. In volunteers, the ECV was associated with age (r=0.74, p< 0.001), maximal LA volume index (r=0.67, p< 0.001), and indexed LV mass. There were no differences in the ECV between segments in a slice or between slices. In mice (n=12) the myocardial ECV ranged from 0.20 to 0.32 and increased with age (0.22 ± 0.02 vs. 0.30 ± 0.02, juvenile vs. aged mice, p< 0.001). In mice, the ECV correlated with the extent of myocardial fibrosis (r=0.94, p< 0.001). In healthy volunteers, the myocardial ECV ranges from 0.23 to 0.33, has acceptable test characteristics, and is associated with age, LA volume, and LV mass. In mice, the ECV also increases with age and strongly correlates with the extent of myocardial fibrosis.
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DOI：
10.1161/circimaging.108.842096
发表时间：
2010-11
期刊：
Circulation. Cardiovascular imaging
影响因子：
--
作者：
Broberg CS;Chugh SS;Conklin C;Sahn DJ;Jerosch-Herold M
通讯作者：
Jerosch-Herold M
DOI：
10.1152/ajpheart.00429.2008
发表时间：
2008-09-01
影响因子：
4.8
作者：
Jerosch-Herold, Michael;Sheridan, David C.;Hershberger, Ray E.
通讯作者：
Hershberger, Ray E.
影响因子：
120.7
作者：
Redfield, MM;Jacobsen, SJ;Rodeheffer, RJ
通讯作者：
Rodeheffer, RJ
影响因子：
24
作者：
Assomull, Ravi G.;Prasad, Sanjay K.;Pennell, Dudley J.
通讯作者：
Pennell, Dudley J.
影响因子：
2.8
作者：
BENJAMIN, EJ;LEVY, D;SUTTON, MS
通讯作者：
SUTTON, MS