When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistance.
When fats commit crimes: fatty acid metabolism, cancer stemness and therapeutic resistance.
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DOI：
10.1186/s40880-018-0317-9
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发表时间：
2018-07-11
期刊：
影响因子：
--
通讯作者：
Ann DK
中科院分区：
文献类型：
--
作者：
Kuo CY;Ann DK
近年来，脂肪酸代谢在癌症中的作用越来越受到重视，包括合成代谢反应和分解代谢反应。许多研究表明，与脂肪酸合成或脂肪酸氧化有关的基因异常表达与肿瘤的转移、耐药和复发等恶性表型有关。这样的表型也与总肿瘤细胞群体中存在的一小部分独特细胞密切相关。这种独特的细胞群可能具有自我更新和繁殖的能力，或者可能能够独立于基因改变而对癌症治疗产生抵抗力。因此，这些细胞被称为癌症干细胞/肿瘤启动细胞/耐药持久性细胞，它们往往对癌症治疗无效，很难靶向。此外，癌细胞和癌症干细胞/肿瘤起始细胞/耐药持续体之间的相互转化可能会发生，从而使治疗更具挑战性。本文重点介绍了脂肪酸代谢、肿瘤干性和治疗耐药之间关系的最新研究结果，并对脂肪酸代谢调节癌细胞命运和治疗耐药的潜在机制进行了讨论。
The role of fatty acid metabolism, including both anabolic and catabolic reactions in cancer has gained increasing attention in recent years. Many studies have shown that aberrant expression of the genes involved in fatty acid synthesis or fatty acid oxidation correlate with malignant phenotypes including metastasis, therapeutic resistance and relapse. Such phenotypes are also strongly associated with the presence of a small percentage of unique cells among the total tumor cell population. This distinct group of cells may have the ability to self-renew and propagate or may be able to develop resistance to cancer therapies independent of genetic alterations. Therefore, these cells are referred to as cancer stem cells/tumor-initiating cells/drug-tolerant persisters, which are often refractory to cancer treatment and difficult to target. Moreover, interconversion between cancer cells and cancer stem cells/tumor-initiating cells/drug-tolerant persisters may occur and makes treatment even more challenging. This review highlights recent findings on the relationship between fatty acid metabolism, cancer stemness and therapeutic resistance and prompts discussion about the potential mechanisms by which fatty acid metabolism regulates the fate of cancer cells and therapeutic resistance.
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DOI：
10.1007/s12032-014-0391-z
发表时间：
2015-01
期刊：
Medical oncology (Northwood, London, England)
影响因子：
--
作者：
Cai Y;Wang J;Zhang L;Wu D;Yu D;Tian X;Liu J;Jiang X;Shen Y;Zhang L;Ren M;Huang P
通讯作者：
Huang P
影响因子：
3.3
作者：
De Pergola G;Silvestris F
通讯作者：
Silvestris F
影响因子：
8.8
作者：
Bjornson, Elias;Mukhopadhyay, Bani;Mardinoglu, Adil
通讯作者：
Mardinoglu, Adil
Nanog通过氧化磷酸化和脂肪酸代谢的肿瘤性变化来代谢重新编程肿瘤发射类样细胞。
影响因子：
29
作者：
Chen CL;Uthaya Kumar DB;Punj V;Xu J;Sher L;Tahara SM;Hess S;Machida K
通讯作者：
Machida K
影响因子：
--
作者：
De Luca A;Fiorillo M;Peiris-Pagès M;Ozsvari B;Smith DL;Sanchez-Alvarez R;Martinez-Outschoorn UE;Cappello AR;Pezzi V;Lisanti MP;Sotgia F
通讯作者：
Sotgia F