A Simple Subjective Evaluation of Enface OCT Reflectance Images Distinguishes Glaucoma From Healthy Eyes.
A Simple Subjective Evaluation of Enface OCT Reflectance Images Distinguishes Glaucoma From Healthy Eyes.
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DOI：
10.1167/tvst.10.6.31
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发表时间：
2021-05-03
影响因子：
3
通讯作者：
Denniss J
中科院分区：
文献类型：
--
作者：
Cheloni R;Dewsbery SD;Denniss J
我们提出了一种主观的方法来检测enface图像中的肿瘤缺陷，并评估其诊断性能。我们还测试了假设，如果反射率的变化之前，厚度的变化，青光眼之间的相关性应该减少的方式相比，控制。20名青光眼参与者和20名年龄匹配的对照者对一只眼睛进行了高分辨率OCT扫描。通过视网膜构建4 μ m厚的enface板。Enface指数是可见的视网膜神经纤维束（RNFB）中的第一个间隙和最后一个可见束的深度，在视盘周围3.5 mm圆的六个扇区中进行主观评价。视网膜神经纤维层厚度（RNFLT）沿沿着相同的圆提取相应的角度enface指数。采用线性混合模型检验组间差异。通过部分受试者工作特征面积（pAUC）测量诊断性能。 青光眼组第一间隙和最后可见束距离内界膜较近（P均< 0.0001）。Enface指数显示出极好的诊断性能（pAUC 0.63-1.00），与RNFLT（pAUC 0.63-0.95）相似。在健康眼（r = 0.81-0.92）和青光眼眼（r = 0.73-0.80）中，enface和RNFLT参数之间的相关性很强。这种简单的主观方法可以可靠地识别表面图像中的软组织缺陷，其诊断性能至少与现有的厚度指数一样好。厚度和反射率在健康眼和青光眼眼中也有类似的相关性，没有提供变薄前反射率损失的有力证据。客观分析可以进一步认识到OCT图像在青光眼中的潜力。新的enface OCT指数可能有助于青光眼诊断。
We present a subjective approach to detecting glaucomatous defects in enface images and assess its diagnostic performance. We also test the hypothesis that if reflectivity changes precede thickness changes in glaucoma there should be reduced correlation between the modalities in glaucoma compared to controls. Twenty glaucoma participants and 20 age-matched controls underwent high-resolution OCT scans of one eye. 4 µm-thick enface slabs were constructed through the retina. Enface indices were depths of first gap in visible retinal nerve fiber bundles (RNFBs) and last visible bundle, subjectively evaluated in six sectors of a 3.5 mm circle around the optic disc. Retinal nerve fiber layer thickness (RNFLT) along the same circle was extracted at angles corresponding to enface indices. Between-group differences were tested by linear mixed models. Diagnostic performance was measured by partial receiver operating characteristic area (pAUC). First gap and last visible bundle were closer to the inner limiting membrane in glaucoma eyes (both P < 0.0001). Enface indices showed excellent diagnostic performance (pAUCs 0.63–1.00), similar to RNFLT (pAUCs 0.63–0.95). Correlation between enface and RNFLT parameters was strong in healthy (r = 0.81–0.92) and glaucoma eyes (r = 0.73–0.80). This simple subjective method reliably identifies glaucomatous defects in enface images with diagnostic performance at least as good as existing thickness indices. Thickness and reflectivity were similarly related in healthy and glaucoma eyes, providing no strong evidence of reflectivity loss preceding thinning. Objective analyses may realize further potential of enface OCT images in glaucoma. Novel enface OCT indices may aid glaucoma diagnosis.
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影响因子：
13.7
作者：
Chen, Teresa C.;Hoguet, Ambika;Chen, Philip P.
通讯作者：
Chen, Philip P.
影响因子：
3
作者：
Denniss, Jonathan;McKendrick, Allison M.;Turpin, Andrew
通讯作者：
Turpin, Andrew
影响因子：
--
作者：
BLAND, JM;ALTMAN, DG
通讯作者：
ALTMAN, DG
影响因子：
3.8
作者：
Bakdash JZ;Marusich LR
通讯作者：
Marusich LR
DOI：
10.1111/opo.12449
发表时间：
2018-07
期刊：
Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists)
影响因子：
--
作者：
Ashimatey BS;King BJ;Burns SA;Swanson WH
通讯作者：
Swanson WH