Evaluating glaucomatous abnormality in peripapillary optical coherence tomography enface visualisation of the retinal nerve fibre layer reflectance.
Evaluating glaucomatous abnormality in peripapillary optical coherence tomography enface visualisation of the retinal nerve fibre layer reflectance.
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DOI：
10.1111/opo.12449
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发表时间：
2018-07
期刊：
影响因子：
--
通讯作者：
Swanson WH
中科院分区：
文献类型：
--
作者：
Ashimatey BS;King BJ;Burns SA;Swanson WH
已经发现光学相干断层扫描（OCT）对视网膜神经纤维层（RNFL）反射率的正面可视化比视网膜厚度测量具有一些优势。然而，目前尚不清楚表面图像上的异常如何与其他临床测量（如视乳头周围视网膜神经纤维层厚度（cRNFLT））的异常结果相关。我们开发了一种技术来分析OCT表面图像上的RNFL反射率，并研究其与cRNFL LT的关系。对31例对照和33例患者（年龄分别为61（±9）岁和69（±8）岁）的研究眼进行了中央视网膜±24°的Spectralis（http：www.heidelbergengineering.com）OCT扫描。分别从颞中缝、中央凹周围和椎间盘区域的内界膜提取16-24、24-36和24-52 μm的Enface平板图像。根据对照数据生成患者的反射概率图。当反射异常的板片面积大于对照组的第95百分位数时，在板片图像上定义青光眼异常，当厚度测量值小于对照组的第5百分位数时，在cRNFLT上定义青光眼异常。使用斯皮尔曼rho，将患者组中显示反射率异常的平板图像分数与cRNFLT进行比较。使用Cohen kappa评估了基于cRNFLT和平板图像反射率的异常结果之间的一致性。26/33只眼的平板图像和cRNFLT结果一致; 4例受试者显示cRNFLT异常，但平板图像无异常，3例受试者显示平板图像异常，但cRNFLT无异常。斯皮尔曼的ρ发现rs（31）= −0.82。27/33例患者的上级颞叶（ST）和颞叶下（IT）的反射率结果和cRNFLT结果一致，Cohen kappa值分别为0.53和0.61。显示RNFL反射率的表面平板图像的表面积与cRNFLT测量值密切相关，并且基于表面反射率结果和cRNFLT结果对青光眼受试者的分类通常具有良好的一致性。通过enface方法评估的较大视网膜区域保留了RNFL异常的空间位置，并且使得该技术成为用于识别针对目标视野检查的潜在RNFL异常区域的有用方法。
Optical coherence tomography (OCT) enface visualisation of the retinal nerve fibre layer (RNFL) reflectance has been found to have some advantages over retinal thickness measures. However, it is not yet clear how abnormalities on enface images relate to findings of abnormalities from other clinical measures such as the circumpapillary retinal nerve fibre layer thickness (cRNFLT). We developed a technique to analyse the RNFL reflectance on the OCT enface images, and to investigate its relation with the cRNFLT. Spectralis (http://www.heidelbergengineering.com) OCT scans of the central retinal ±24° were analysed in the study eye of 31 controls and 33 patients, ages 61 (±9) and 69 (±8) years respectively. Enface slab‐images were extracted at 16–24, 24–36, and 24–52 μm from the inner limiting membrane in the temporal raphe, perifoveal and disc regions respectively. Reflectance probability maps were generated for the patients based on the control data. Glaucomatous abnormality was defined on the slab‐images when the slab‐area with reflectance abnormality was greater than the 95th percentile, and on the cRNFLT when the thickness measure was less than the fifth percentile, of that found in controls. The fraction of slab‐image showing reflectance abnormality was compared to cRNFLT in the patient group, using Spearman's rho. Agreement between the findings of abnormality based on cRNFLT and slab‐image reflectance was assessed using Cohen's kappa. Slab‐image and cRNFLT findings were in agreement for 26/33 eyes; four subjects showed cRNFLT abnormality but not slab‐image abnormality, and three subjects showed slab‐image abnormality but not cRNFLT abnormality. Spearman's rho found r s(31) = −0.82. The reflectance findings and cRNFLT findings were consistent in 27/33 for both the superior temporal (ST) and inferior temporal (IT) sectors, and Cohen's kappa found 0.53 and 0.61 respectively. The surface area of enface slab‐images showing RNFL reflectance were strongly related to the cRNFLT measures, and the classification of a subject with glaucoma based on enface reflectance findings and cRNFLT findings had a generally good agreement. The larger retinal area assessed by the enface method preserves the spatial location of the RNFL abnormalities, and makes the technique a useful approach for identifying regions of potential RNFL abnormality for targeted perimetry.
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DOI：
10.1097/opx.0000000000000395
发表时间：
2014-11
期刊：
Optometry and vision science : official publication of the American Academy of Optometry
影响因子：
--
作者：
Swanson WH;Malinovsky VE;Dul MW;Malik R;Torbit JK;Sutton BM;Horner DG
通讯作者：
Horner DG
影响因子：
4.4
作者：
Girard, Michael J. A.;Strouthidis, Nicholas G.;Mari, Jean Martial
通讯作者：
Mari, Jean Martial
影响因子：
2.9
作者：
Ashimatey, Bright S.;King, Brett J.;Swanson, William H.
通讯作者：
Swanson, William H.
影响因子：
0.8
作者：
Grieshaber, M. C.;Moramarco, F.;Orguel, S.
通讯作者：
Orguel, S.
影响因子：
4.2
作者：
VRABEC, F
通讯作者：
VRABEC, F