Association of Homocysteine with Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.
Association of Homocysteine with Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.
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同型半胱氨酸与高血压患者无症状颅内和颅外动脉狭窄的关联。
DOI：
10.1038/s41598-017-19125-9
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发表时间：
2018-01-12
影响因子：
4.6
通讯作者：
Zhu D
中科院分区：
文献类型：
--
作者：
Wang Y;Zhang J;Qian Y;Tang X;Ling H;Chen K;Li Y;Gao P;Zhu D
血浆同型半胱氨酸（Hcy）升高被认为是卒中的独立危险因素。本研究旨在探讨Hcy浓度与中国人群无脑卒中高血压患者颅内动脉粥样硬化（ICAS）和颅外动脉粥样硬化（ECAS）的关系，并探讨亚甲基四氢叶酸还原酶（MTHFR） C677T在两者关系中的调节作用。通过主动脉弓至颅底的计算机断层血管造影（CTA）对929例患者颅内和颅外动脉狭窄情况进行评估。当Hcy浓度增加1µmol/L时，Hcy浓度与ICAS （OR: 1.105; 95% CI: 1.057 ~ 1.155）和ECAS （OR: 1.096; 95% CI: 1.047 ~ 1.146）显著相关。同时，充分调整后，高同型半胱氨酸血症（≥15µmol/L）与ICAS （OR: 1.587; 95% CI: 1.029-2.446）和ECAS （OR: 2.164; 95% CI: 1.392-3.364）也显示出相关性。此外，在亚组分析中，这种相关性仅在较年轻、肾功能正常且携带MTHFR 677 C等位基因的受试者中保持显著。我们的研究显示Hcy与无症状高血压患者的ECAS和ICAS有显著的相关性。Hcy对颈-脑动脉粥样硬化具有普遍作用。这种关联被MTHFR C677T基因型修饰。
Elevated plasma homocysteine (Hcy) is suggested as an independent risk factor for stroke. We aimed to investigate the association of Hcy concentration with intracranial atherosclerosis (ICAS) and extracranial AS (ECAS) in hypertensive patients without stroke in Chinese population and to explore modified effect of methylenetetrahydrofolate reductase (MTHFR) C677T on their relationship. The stenosis of intracranial and extracranial arteries were evaluated in a total of 929 subjects through computerized tomographic angiography (CTA) from aortic arch to the skull base. Hcy concentration showed significantly association with both ICAS (OR: 1.105; 95% CI: 1.057–1.155) and ECAS (OR: 1.096; 95% CI: 1.047–1.146) for 1 µmol/L increment in Hcy. Meanwhile, hyperhomocysteinemia (≥15 µmol/L) was also displayed association with ICAS (OR: 1.587; 95% CI: 1.029–2.446) and ECAS (OR: 2.164; 95% CI: 1.392–3.364) after fully adjustment. Furthermore, in the subgroup analysis, such association remained significant only in the subjects that were younger, with normal renal function and with MTHFR 677 C allele. Our study showed the significant association of Hcy with ECAS and ICAS in asymptomatic hypertension patients. Hcy played a universal effect on the cervico-cerebral atherosclerosis. Such association was modified by the MTHFR C677T genotype.
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影响因子：
8.3
作者：
Rundek T;Blanton SH;Bartels S;Dong C;Raval A;Demmer RT;Cabral D;Elkind MS;Sacco RL;Desvarieux M
通讯作者：
Desvarieux M
影响因子：
120.7
作者：
Graham, IM;Daly, LE;Andria, G
通讯作者：
Andria, G
影响因子：
8.3
作者：
Anderson, GB;Ashforth, R;Findlay, JM
通讯作者：
Findlay, JM
DOI：
10.1016/j.jash.2014.12.020
发表时间：
2015-03-01
影响因子：
--
作者：
Catena, Cristiana;Colussi, GianLuca;Sechi, Leonardo A.
通讯作者：
Sechi, Leonardo A.
叶酸治疗对中国成人高血压患者脑卒中一级预防的疗效 CSPPT 随机临床试验
影响因子：
120.7
作者：
Huo, Yong;Li, Jianping;Hou, Fan Fan
通讯作者：
Hou, Fan Fan