Designing in vivo concentration gradients with discrete controlled release: a computational model.
Designing in vivo concentration gradients with discrete controlled release: a computational model.
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DOI：
10.1088/1741-2560/7/4/046013
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发表时间：
2010-08
影响因子：
4
通讯作者：
Barbour DL
中科院分区：
文献类型：
--
作者：
Walker EY;Barbour DL
One promising neurorehabilitation therapy involves presenting neurotrophins directly into the brain to induce the growth of new neural connections. The precise control of neurotrophin concentration gradients deep within neural tissue that would be necessary for such a therapy is not currently possible, however. Here we evaluate the theoretical potential of a novel method of drug delivery, discrete controlled release or DCR, to control effective neurotrophin concentration gradients in an isotropic region of neocortex. We do so by constructing computational models of neurotrophin concentration profiles resulting from discrete release locations into the cortex and then optimizing their design for uniform concentration gradients. The resulting model indicates that by rationally selecting initial neurotrophin concentrations for drug-releasing electrode coatings in a square 16-electrode array, nearly uniform concentration gradients (i.e., planar concentration profiles) from one edge of the electrode array to the other should be obtainable. Discrete controlled release therefore represents a promising new method of precisely directing neuronal growth in vivo over a wider spatial profile than would be possible with single release points.
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影响因子：
5.3
作者：
Bagnard, D;Thomasset, N;Bolz, J
通讯作者：
Bolz, J
影响因子：
3.8
作者：
Li, Grace N.;Liu, Jeffrey;Hoffman-Kim, Diane
通讯作者：
Hoffman-Kim, Diane
影响因子：
2.9
作者：
KREWSON, CE;KLARMAN, ML;SALTZMAN, WM
通讯作者：
SALTZMAN, WM
影响因子：
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作者：
Mahoney, Melissa J.;Krewson, Christine;Saltzman, W. Mark
通讯作者：
Saltzman, W. Mark
影响因子：
5.3
作者：
HOFFMAN, D;WAHLBERG, L;AEBISCHER, P
通讯作者：
AEBISCHER, P