Brain organoids are new tool for drug screening of neurological diseases.
Brain organoids are new tool for drug screening of neurological diseases.
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DOI：
10.4103/1673-5374.367983
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发表时间：
2023-09
影响因子：
6.1
通讯作者：
Gao C
中科院分区：
文献类型：
--
作者：
Zhou JQ;Zeng LH;Li CT;He DH;Zhao HD;Xu YN;Jin ZT;Gao C
在药物体外筛选层面，以高含量筛选为核心的表型分析系统的开发，为高通量药物筛选提供了有力的支撑平台。脑有机化合物作为一种新型的三维体外模型，在模型稳定性、关键表型指纹图谱、药物筛选方案等方面鲜有系统报道，尤其是大量中药单体筛选策略的发展。本文综述了脑有机体的发展及其在模拟疾病中相对于诱导神经元或细胞的优势。从模型的稳定性、脑有机化合物的诱导标准、基于脑有机化合物特性的脑有机化合物筛选方案以及高含量筛选系统的应用和发展等方面进行了展望。
At the level of in vitro drug screening, the development of a phenotypic analysis system with high-content screening at the core provides a strong platform to support high-throughput drug screening. There are few systematic reports on brain organoids, as a new three-dimensional in vitro model, in terms of model stability, key phenotypic fingerprint, and drug screening schemes, and particularly regarding the development of screening strategies for massive numbers of traditional Chinese medicine monomers. This paper reviews the development of brain organoids and the advantages of brain organoids over induced neurons or cells in simulated diseases. The paper also highlights the prospects from model stability, induction criteria of brain organoids, and the screening schemes of brain organoids based on the characteristics of brain organoids and the application and development of a high-content screening system.
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影响因子：
48
作者：
Bian S;Repic M;Guo Z;Kavirayani A;Burkard T;Bagley JA;Krauditsch C;Knoblich JA
通讯作者：
Knoblich JA
影响因子：
64.5
作者：
Andersen J;Revah O;Miura Y;Thom N;Amin ND;Kelley KW;Singh M;Chen X;Thete MV;Walczak EM;Vogel H;Fan HC;Paşca SP
通讯作者：
Paşca SP
影响因子：
11
作者：
Gonzalez C;Armijo E;Bravo-Alegria J;Becerra-Calixto A;Mays CE;Soto C
通讯作者：
Soto C
DOI：
10.3390/microarrays2020063
发表时间：
2013-04-03
期刊：
Microarrays (Basel, Switzerland)
影响因子：
--
作者：
Kwon YJ;Heo JY;Kim HC;Kim JY;Liuzzi M;Soloveva V
通讯作者：
Soloveva V
影响因子：
5.6
作者：
Costamagna G;Comi GP;Corti S
通讯作者：
Corti S