Menopausal symptoms among breast cancer patients 6 months after diagnosis: a report from the Shanghai Breast Cancer Survival Study.
Menopausal symptoms among breast cancer patients 6 months after diagnosis: a report from the Shanghai Breast Cancer Survival Study.
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DOI：
10.1097/gme.0b013e3181aac32b
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Shu XO
中科院分区：
文献类型：
--
作者：
Dorjgochoo T;Gu K;Kallianpur A;Zheng Y;Zheng W;Chen Z;Lu W;Shu XO
评估接受乳腺癌治疗的亚洲女性中与治疗方式相关的绝经期症状的患病率。从基于人群的肿瘤登记研究中确定了一个基于人群的队列，其中包括5，023名年龄在20-75岁之间的原发性0-III期乳腺癌中国女性，并在诊断后约6个月入组研究。询问患者特定绝经期症状的发生情况。这些症状和乳腺癌治疗之间的关联通过分层多变量逻辑回归进行评估。67.2%的绝经前女性和46.3%的绝经后女性最近患过乳腺癌，经历过至少一种绝经期症状，即潮热、盗汗和/或阴道干燥。绝经后妇女的症状患病率随着诊断时年龄的增加而逐渐降低（51-55岁妇女为63.3%，56-60岁妇女为51.5%，>65岁妇女为34.4%[P<0.01]）。总体而言，大多数症状的患病率最高发生在46-55岁的妇女（P<0.01）。化疗与任何症状的发生以及与每种个体症状的发生呈正相关，主要发生在绝经前妇女中[校正比值比（ORadj）范围为2.2-3.3（所有P值<0.05）]。无论绝经状态如何，他莫昔芬使用和免疫治疗与任何症状和每种症状相关（ORadj范围：分别为1.5-1.8和1.3-1.5;所有P <0.05）。绝经前接受化疗的妇女在化疗后出现≥2种症状的风险特别高（OR=1.77，95% CI 1.54-4.98，P相互作用=0.05）。月经症状在最近接受原发性乳腺癌治疗的中国女性中很普遍。这些症状与诊断时的年龄和绝经状态以及接受的治疗类型有关。
To estimate the prevalence of menopausal symptoms in relation to treatment modalities in Asian women treated for breast cancer. A population-based cohort of 5,023 Chinese women aged 20–75 years with primary stage 0-III breast cancer was identified from a population-based tumor-registry and enrolled in the study approximately 6 months after diagnosis. Patients were asked about the occurrence of specific menopausal symptoms. Associations between these symptoms and breast cancer treatments were evaluated by stratified, multivariate logistic regression. 67.2% of premenopausal women and 46.3% of postmenopausal women with a recent breast cancer experienced at least one menopausal symptom, namely hot flashes, night sweats and/or vaginal dryness. Symptom prevalence among postmenopausal women decreased progressively with age at diagnosis (63.3% for women 51–55, 51.5% for women 56–60, and 34.4% for women >65 years [P<0.01]). Overall, the highest prevalence of most symptoms occurred in women aged 46–55 years (P<0.01). Chemotherapy was positively associated with the occurrence of any symptom and with each individual symptom, mainly in premenopausal women [adjusted odds ratios (ORadj) range of 2.2–3.3 (all P-values<0.05)]. Tamoxifen use and immunotherapy were associated with having any symptom and with each individual symptom, regardless of menopausal status (ORadj range: 1.5–1.8 and 1.3–1.5, respectively; P <0.05 for all). Women treated before menopause were at particularly high risk of experiencing ≥2 symptoms after chemotherapy (OR=1.77, 95% CI 1.54–4.98, Pinteraction =0.05). Menopausal symptoms are prevalent among Chinese women recently treated for primary breast cancer. These symptoms are associated with age and menopausal status at the time of diagnosis, as well as with the type of treatment received.
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影响因子：
12.7
作者：
Gold, Ellen B.;Colvin, Alicia;Matthews, Karen
通讯作者：
Matthews, Karen
DOI：
10.1093/jnci/93.21.1615
发表时间：
2001-11-07
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Day, R;Ganz, PA;Costantino, JP
通讯作者：
Costantino, JP
影响因子：
5.8
作者：
Barbieri, Robert L.
通讯作者：
Barbieri, Robert L.
影响因子：
50.5
作者：
Leining, M. G.;Gelber, S.;Partridge, A. H.
通讯作者：
Partridge, A. H.
影响因子：
4.9
作者：
Haines, CJ;Xing, SM;Ausmanas, MK
通讯作者：
Ausmanas, MK