Is personality associated with dementia risk? A meta-analytic investigation.
Is personality associated with dementia risk? A meta-analytic investigation.
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DOI：
10.1016/j.arr.2021.101269
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发表时间：
2021-05
影响因子：
13.1
通讯作者：
Terracciano A
中科院分区：
文献类型：
--
作者：
Aschwanden D;Strickhouser JE;Luchetti M;Stephan Y;Sutin AR;Terracciano A
本研究对人格特质（神经质、外向性、开放性、宜人性、尽责性）与阿尔茨海默病及相关痴呆发病风险之间的潜在关联进行了定量综合。我们对8-12个样本（N = 30,036至33,054）进行了5次独立的荟萃分析，这些样本是根据MOOSE指南通过系统文献检索确定的。高神经质（HR = 1.24, 95% CI[1.17, 1.31]）和低责任心（HR = 0.77, 95% CI[0.73, 0.81]）与痴呆风险增加相关，即使在考虑了抑郁症状等协变量后也是如此。较低的外向性（HR = 0.92, 95% CI[0.86, 0.97]）、开放性（HR = 0.91, 95% CI[0.86, 0.96]）和亲和性（HR = 0.90, 95% CI[0.83, 0.98]）也与风险增加相关，但这些关联在完全调整后的模型中不太稳健且不显著。未发现发表偏倚的证据。协会的强度与出版年份无关（即，没有证据表明胜利者的诅咒）。meta回归表明，在评估痴呆、痴呆类型、随访时间、样本年龄、少数民族、国家和个性的方法中，神经质、开放性和尽责性的影响是一致的。外向性和宜人性的关系因国家而异。我们的研究结果表明，神经质和尽责性与痴呆风险有很强的联系。
This study provides a quantitative synthesis of the prospective associations between personality traits (neuroticism, extraversion, openness, agreeableness, conscientiousness) and the risk of incident Alzheimer’s disease and related dementias. We conducted five separate meta-analyses with 8–12 samples (N = 30,036 to 33,054) that were identified through a systematic literature search following the MOOSE guidelines. Higher neuroticism (HR = 1.24, 95% CI [1.17, 1.31]) and lower conscientiousness (HR = 0.77, 95% CI [0.73, 0.81]) were associated with increased dementia risk, even after accounting for covariates such as depressive symptoms. Lower extraversion (HR = 0.92, 95% CI [0.86, 0.97]), openness (HR = 0.91, 95% CI [0.86, 0.96]), and agreeableness (HR = 0.90, 95% CI [0.83, 0.98]) were also associated with increased risk, but these associations were less robust and not significant in fully adjusted models. No evidence of publication bias was found. The strength of associations was unrelated to publication year (i.e., no evidence of winner’s curse). Meta-regressions indicated consistent effects for neuroticism, openness, and conscientiousness across methods to assess dementia, dementia type, follow-up length, sample age, minority, country, and personality measures. The association of extraversion and agreeableness varied by country. Our findings indicate robust associations of neuroticism and conscientiousness with dementia risk.
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DOI：
10.1177/2515245919847196
发表时间：
2019-06-01
影响因子：
13.6
作者：
Carter, Evan C.;Schonbrodt, Felix D.;Hilgard, Joseph
通讯作者：
Hilgard, Joseph
影响因子：
14
作者：
通讯作者：
--
影响因子：
1.9
作者：
Duval, S;Tweedie, R
通讯作者：
Tweedie, R
影响因子：
1
作者：
Aschwanden D;Sutin AR;Luchetti M;Stephan Y;Terracciano A
通讯作者：
Terracciano A
影响因子：
25.8
作者：
Chapman, Benjamin P.;Huang, Alison;Lapham, Susan
通讯作者：
Lapham, Susan