PTSD is associated with increased DNA methylation across regions of HLA-DPB1 and SPATC1L.
PTSD is associated with increased DNA methylation across regions of HLA-DPB1 and SPATC1L.
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DOI：
10.1016/j.bbi.2020.10.023
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Smith AK
中科院分区：
文献类型：
--
作者：
Katrinli S;Zheng Y;Gautam A;Hammamieh R;Yang R;Venkateswaran S;Kilaru V;Lori A;Hinrichs R;Powers A;Gillespie CF;Wingo AP;Michopoulos V;Jovanovic T;Wolf EJ;McGlinchey RE;Milberg WP;Miller MW;Kugathasan S;Jett M;Logue MW;Ressler KJ;Smith AK
创伤后应激障碍（PTSD）的特征是侵入性思想、逃避、认知和情绪的负面改变以及对身心健康产生不利影响的觉醒症状。最近的证据表明，CpG基因甲基化的变化与PTSD有关。由于近端CpGs簇具有相似的甲基化特征，鉴定PTSD相关的差异甲基化区域（DMRs）可能阐明界定PTSD差异风险和恢复能力的途径。在这里，我们的目的是确定与PTSD相关的表观遗传差异。使用MethylationEPIC BeadChip从血液样本中提取DNA甲基化数据，对格雷迪创伤项目（GTP）的187例创伤后应激障碍病例和367例创伤暴露对照组进行DMR分析。采用R包bumphounter对dmr进行评估。经过多次测试校正，我们确定了两个与PTSD相关的区域。这些区域位于HLA-DPB1基因体和SPATC1L启动子中。在一个独立的队列中，HLA-DPB1中的DMR与PTSD相关。两种DMRs都包含CpGs，其甲基化与附近序列变异（meQTL）相关，与各自基因的表达（eQTM）相关。这项研究支持了将创伤后应激障碍风险与HLA区域遗传和表观遗传变异联系起来的新兴文献。
Posttraumatic stress disorder (PTSD) is characterized by intrusive thoughts, avoidance, negative alterations in cognitions and mood, and arousal symptoms that adversely affect mental and physical health. Recent evidence links changes in DNA methylation of CpG cites to PTSD. Since clusters of proximal CpGs share similar methylation signatures, identification of PTSD-associated differentially methylated regions (DMRs) may elucidate the pathways defining differential risk and resilience of PTSD. Here we aimed to identify epigenetic differences associated with PTSD. DNA methylation data profiled from blood samples using the MethylationEPIC BeadChip were used to perform a DMR analysis in 187 PTSD cases and 367 trauma-exposed controls from the Grady Trauma Project (GTP). DMRs were assessed with R package bumphunter. We identified two regions that associate with PTSD after multiple test correction. These regions were in the gene body of HLA-DPB1 and in the promoter of SPATC1L. The DMR in HLA-DPB1 was associated with PTSD in an independent cohort. Both DMRs included CpGs whose methylation associated with nearby sequence variation (meQTL) and that associated with expression of their respective genes (eQTM). This study supports an emerging literature linking PTSD risk to genetic and epigenetic variation in the HLA region.
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影响因子：
25.8
作者：
Eraly, Satish A.;Nievergelt, Caroline M.;Maihofer, Adam X.;Barkauskas, Donald A.;Biswas, Nilima;Agorastos, Agorastos;O'Connor, Daniel T.;Baker, Dewleen G.
通讯作者：
Baker, Dewleen G.
影响因子：
25
作者：
Gelernter, Joel;Sun, Ning;Stein, Murray B.
通讯作者：
Stein, Murray B.
最新的遗传学和表观遗传学方法是PTSD。
影响因子：
6.7
作者：
Daskalakis NP;Rijal CM;King C;Huckins LM;Ressler KJ
通讯作者：
Ressler KJ
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
2.5
作者：
BRETDIBAT, JL;KENT, S;DANTZER, R
通讯作者：
DANTZER, R