Comparison of three different techniques of low-dose-rate seed implantation for prostate cancer.
Comparison of three different techniques of low-dose-rate seed implantation for prostate cancer.
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DOI：
10.5114/jcb.2015.48603
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发表时间：
2015-02
影响因子：
1.4
通讯作者：
Hayakawa K
中科院分区：
文献类型：
--
作者：
Ishiyama H;Satoh T;Sekiguchi A;Tabata K;Komori S;Tsumura H;Kawakami S;Soda I;Takenaka K;Iwamura M;Hayakawa K
自我院开始使用低剂量率粒子植入治疗前列腺癌以来，已使用了三种不同的技术。本研究的目的是比较三种不同技术的结果。回顾性分析了305例接受低剂量率粒子植入治疗的前列腺癌患者的资料。按时间顺序尝试了预先计划技术（n = 27）、术中预先计划技术（n = 86）和交互式计划技术（n = 192）。处方剂量设定为145戈伊。中位随访时间为66个月（范围：12-94个月）。5年生化控制率为95.5%（术前计划组：100%，术中术前计划组：90.7%，交互计划组：97.0%; p = 0.08）。从预先计划组到交互组，剂量测定参数通常增加。与其他技术相比，使用交互式计划，计划阶段和CT分析之间的某些剂量学参数差异显著减少。与其他两组相比，交互式计划显示出种子迁移率显著降低。急性泌尿生殖系统毒性、急性胃肠道毒性、频率和尿潴留从预计划期到交互计划期逐渐增加。三组间生化控制无显著性差异。剂量体积参数从预先计划技术增加到交互计划技术。然而，这可能不一定是由于技术改进，因为剂量递增是在同一时期开始的。较低的粒子迁移率和计划阶段与采用交互式计划技术的CT分析之间的较小差异表明该技术优于其他两种技术。
Three different techniques of low-dose-rate seed implantation for prostate cancer have been used since its use started in our hospital. The purpose of this study was to compare the results of the three different techniques. The data of 305 prostate cancer patients who underwent low-dose-rate seed implantation were retrospectively analyzed. Pre-plan technique (n = 27), intraoperative pre-plan technique (n = 86), and interactive plan technique (n = 192) were tried in chronological order. The prescribed dose was set at 145 Gy. Median follow-up was 66 months (range: 12-94 months). The 5-year biochemical control rate was 95.5% (pre-plan group: 100%, intraoperative pre-plan group: 90.7%, interactive plan group: 97.0%; p = 0.08). Dosimetric parameters were generally increased from the pre-plan group to the interactive group. The differences in some dosimetric parameters between the planning phase and the CT analysis were significantly reduced with the interactive plan compared to the other techniques. The interactive plan showed a significant reduction of the seed migration rate compared to the two other groups. Acute genitourinary toxicity, acute gastrointestinal toxicity, frequency, and urinary retention increased gradually from the pre-plan period to the interactive plan period. There was no significant difference in biochemical control among the three groups. Dose-volume parameters were increased from the pre-plan technique to the interactive plan technique. However, this may not necessarily be due to technical improvements, since dose escalation was started during the same period. Lower seed migration rates and the smaller differences between the planning phase and CT analysis with the interactive plan technique suggest the superiority of this technique to the two other techniques.
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DOI：
10.1016/j.ijrobp.2005.07.981
发表时间：
2006-02-01
影响因子：
7
作者：
Stock, RG;Stone, NN;Rosenstein, BS
通讯作者：
Rosenstein, BS
影响因子：
2.1
作者：
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DOI：
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2002-06-01
影响因子：
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DOI：
10.1016/s0360-3016(00)00734-3
发表时间：
2000-11-01
影响因子：
7
作者：
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通讯作者：
Klein, EA
影响因子：
2.1
作者：
Stone, NN;Stock, RG
通讯作者：
Stock, RG