Evolution of comorbidities in people living with HIV between 2004 and 2014: cross-sectional analyses from ANRS CO3 Aquitaine cohort.
Evolution of comorbidities in people living with HIV between 2004 and 2014: cross-sectional analyses from ANRS CO3 Aquitaine cohort.
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2004年至2014年间艾滋病毒感染者合并症的演变：ANRS CO3阿基坦队列的横断面分析
DOI：
10.1186/s12879-020-05593-4
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发表时间：
2020-11-16
影响因子：
3.7
通讯作者：
Dabis F
中科院分区：
文献类型：
--
作者：
Bonnet F;Le Marec F;Leleux O;Gerard Y;Neau D;Lazaro E;Duffau P;Caubet O;Vandenhende MA;Mercie P;Cazanave C;Dabis F
这项研究的目的是描述法国ANRS CO3阿基坦因前瞻性队列中艾滋病毒携带者(PLHIV)的慢性非艾滋病相关疾病及其风险因素的演变，以改善长期医疗管理。ANRS CO3 Aquiaine队列前瞻性地收集了法国Aquiaine地区PLHIV的流行病学、临床、生物学和治疗数据。2004年和2014年进行了两次横断面分析，以调查患者特征、艾滋病毒RNA、CD4计数以及一些常见合并症和治疗的患病率。2138名艾滋病病毒感染者(71%为男性，2014年年龄中位数为52.2 岁)被确定纳入研究，包括在队列中登记的参与者，他们在2004年和2014年都有至少一次住院记录。确诊的慢性肾脏疾病(CKD)、骨折、心血管事件(CVE)、高血压、糖尿病和血脂异常的患病率显著增加，对这些疾病(他汀类药物、氯吡格雷、阿司匹林)的治疗或预防也有所增加。这也反映在CKD、CVE和骨折评分的疾病风险评分的高风险组或极高风险组患者的比例增加。2004至2014年间，法国ANRS CO3阿基坦大区预期队列中确定的PLHIV老龄化人口经历了包括CKD和CVD在内的非艾滋病毒相关合并症的总体较高患病率。PLHIV的长期医疗管理和长期健康结果可以通过以下方式得到改善：根据当前的建议进行谨慎的艾滋病毒管理，并优化选择抗逆转录病毒药物，并通过建议的生活方式改善和预防措施及早管理合并症。
The objective of the study was to describe the evolution of chronic non-AIDS related diseases and their risk factors, in patients living with HIV (PLHIV) in the French ANRS CO3 Aquitaine prospective cohort, observed both in 2004 and in 2014 in order to improve long-term healthcare management. The ANRS CO3 Aquitaine cohort prospectively collects epidemiological, clinical, biological and therapeutic data on PLHIV in the French Aquitaine region. Two cross sectional analyses were performed in 2004 and 2014, to investigate the patient characteristics, HIV RNA, CD4 counts and prevalence of some common comorbidities and treatment. 2138 PLHIV (71% male, median age 52.2 years in 2014) were identified for inclusion in the study, including participants who were registered in the cohort with at least one hospital visit recorded in both 2004 and 2014. Significant increases in the prevalence of diagnosed chronic kidney disease (CKD), bone fractures, cardiovascular events (CVE), hypertension, diabetes and dyslipidaemia, as well as an increase in treatment or prevention for these conditions (statins, clopidogrel, aspirin) were observed. It was also reflected in the increase in the proportion of patients in the “high” or “very high” risk groups of the disease risk scores for CKD, CVE and bone fracture score. Between 2004 and 2014, the aging PLHIV population identified in the French ANRS CO3 Aquitaine prospective cohort experienced an overall higher prevalence of non-HIV related comorbidities, including CKD and CVD. Long-term healthcare management and long-term health outcomes could be improved for PLHIV by: careful HIV management according to current recommendations with optimal selection of antiretrovirals, and early management of comorbidities through recommended lifestyle improvements and preventative measures.
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影响因子：
4.1
作者：
Wandeler G;Johnson LF;Egger M
通讯作者：
Egger M
影响因子：
3
作者：
Orlando, G.;Meraviglia, P.;Cargnel, A.
通讯作者：
Cargnel, A.
影响因子：
11.8
作者：
Gourlay, Annabelle;Noori, Teymur;Porter, Kholoud
通讯作者：
Porter, Kholoud
DOI：
10.1097/hjr.0b013e328336a150
发表时间：
2010-10-01
影响因子：
--
作者：
Friis-Moller, Nina;Thiebaut, Rodolphe;Law, Matthew G.
通讯作者：
Law, Matthew G.
影响因子：
7.5
作者：
De Socio, Giuseppe Vittorio;Ricci, Elena;Bonfanti, Paolo
通讯作者：
Bonfanti, Paolo