Effectiveness of a Vaping Cessation Text Message Program Among Young Adult e-Cigarette Users: A Randomized Clinical Trial.
Effectiveness of a Vaping Cessation Text Message Program Among Young Adult e-Cigarette Users: A Randomized Clinical Trial.
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DOI：
10.1001/jamainternmed.2021.1793
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发表时间：
2021-07-01
影响因子：
39
通讯作者：
Papandonatos GD
中科院分区：
文献类型：
--
作者：
Graham AL;Amato MS;Cha S;Jacobs MA;Bottcher MM;Papandonatos GD
这项随机临床试验确定了18至24岁的年轻人与仅评估对照组之间的短信戒烟计划的有效性。戒烟短信计划是否能有效促进年轻人（YAs）戒除电子烟？在这项对2588名YA电子烟使用者进行的随机临床试验中，在随机化后7个月，分配到短信干预的参与者的戒烟率为24.1%，分配到仅评估对照组的参与者为18.6%，这是一个统计学显著差异。没有基线特征调节治疗-结果关系，包括尼古丁依赖。一项短信戒烟计划可以有效地促进YA电子烟用户的戒烟。电子烟是年轻人（YAs）中最常用的烟草产品。尽管YAs中尼古丁暴露的危害，但很少有（如果有的话）经过经验测试的戒烟干预措施。确定短信计划在YAs与仅评估对照之间停止吸烟的有效性。于2019年12月至2020年11月在YA电子烟使用者中进行了一项平行、2组、双盲、个体随机临床试验。符合条件的个人是年龄在18至24岁之间的美国居民，他们拥有一部带有活动短信计划的移动的手机，报告过去30天使用电子烟，并有兴趣在未来30天内戒烟。参与者通过社交媒体广告招募，干预通过短信传递，评估通过网站或移动的电话完成。随机化后1个月和7个月进行随访;随访数据收集从2020年1月开始，于2020年11月结束。本研究在试验方案中预先规定。所有参与者每月通过短信接受关于电子烟使用的评估。仅评估对照组（n = 1284）未接受额外干预。主动干预组（n = 1304）还接受了This is Quitting，这是一种用于戒烟的全自动短信程序，可提供社会支持以及认知和行为应对技能培训。主要结果是在意向治疗分析下分析的7个月自我报告的30天点戒烟率（ppa），将无应答者视为vaping。次要结局是意向治疗分析下的7天ppa和30天和7天ppa的保留加权完整病例分析。在纳入试验的2588名YA电子烟使用者中，平均（SD）年龄为20.4（1.7）岁，1253名（48.4%）为男性，2159名（83.4%）为白色，275名（10.6%）为西班牙裔，493名（19.0%）为性少数。大多数参与者（n = 2129; 82.3%）在醒来后30分钟内吸了电子烟。7个月随访率为76.0%（n = 1967），无差异磨损。干预组的戒烟率为24.1%（95%CI，21.8%-26.5%），对照组为18.6%（95%CI，16.7%-20.8%）（比值比，1.39; 95%CI，1.15-1.68; P <0.001）。没有基线变量调节治疗-结果关系，包括尼古丁依赖。这项随机临床试验的结果表明，量身定制的交互式短信干预在促进YAs戒烟方面是有效的。这些结果建立了干预有效性的基准。ClinicalTrials.gov标识符：NCT 04251273
This randomized clinical trial determines the effectiveness of a text message program for vaping cessation among young adults aged 18 to 24 years vs assessment-only control. Is a text message program for vaping cessation effective in promoting abstinence from e-cigarettes among young adults (YAs)? In this randomized clinical trial of 2588 YA e-cigarette users, at 7 months postrandomization abstinence rates were 24.1% among participants assigned to the text message intervention and 18.6% among participants assigned to an assessment-only control, which is a statistically significant difference. No baseline characteristics moderated the treatment-outcome relationship, including nicotine dependence. A text message vaping cessation program is effective in promoting abstinence among YA e-cigarette users. e-Cigarettes are the most commonly used tobacco product among young adults (YAs). Despite the harms of nicotine exposure among YAs, there are few, if any, empirically tested vaping cessation interventions available. To determine the effectiveness of a text message program for vaping cessation among YAs vs assessment-only control. A parallel, 2-group, double-blind, individually randomized clinical trial was conducted from December 2019 to November 2020 among YA e-cigarette users. Eligible individuals were US residents aged 18 to 24 years who owned a mobile phone with an active text message plan, reported past 30-day e-cigarette use, and were interested in quitting in the next 30 days. Participants were recruited via social media ads, the intervention was delivered via text message, and assessments were completed via website or mobile phone. Follow-up was conducted at 1 and 7 months postrandomization; follow-up data collection began January 2020 and ended in November 2020. The study was prespecified in the trial protocol. All participants received monthly assessments via text message about e-cigarette use. The assessment-only control arm (n = 1284) received no additional intervention. The active intervention arm (n = 1304) also received This is Quitting, a fully automated text message program for vaping cessation that delivers social support and cognitive and behavioral coping skills training. The primary outcome was self-reported 30-day point prevalence abstinence (ppa) at 7 months analyzed under intention-to-treat analysis, which counted nonresponders as vaping. Secondary outcomes were 7-day ppa under intention-to-treat analysis and retention weighted complete case analysis of 30-day and 7-day ppa. Of the 2588 YA e-cigarette users included in the trial, the mean (SD) age was 20.4 (1.7) years, 1253 (48.4%) were male, 2159 (83.4%) were White, 275 (10.6%) were Hispanic, and 493 (19.0%) were a sexual minority. Most participants (n = 2129; 82.3%) vaped within 30 minutes of waking. The 7-month follow-up rate was 76.0% (n = 1967), with no differential attrition. Abstinence rates were 24.1% (95% CI, 21.8%-26.5%) among intervention participants and 18.6% (95% CI, 16.7%-20.8%) among control participants (odds ratio, 1.39; 95% CI, 1.15-1.68; P < .001). No baseline variables moderated the treatment-outcome relationship, including nicotine dependence. Results of this randomized clinical trial demonstrated that a tailored and interactive text message intervention was effective in promoting vaping cessation among YAs. These results establish a benchmark of intervention effectiveness. ClinicalTrials.gov Identifier: NCT04251273
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影响因子：
4.4
作者：
Cohn, Amy;Villanti, Andrea;Mermelstein, Robin
通讯作者：
Mermelstein, Robin
影响因子：
4.2
作者：
Romberg, Alexa R.;Lo, Erin J. Miller;King, Brian A.
通讯作者：
King, Brian A.
影响因子：
2.4
作者：
Buu, Anne;Hu, Yi-Han;Lin, Hsien-Chang
通讯作者：
Lin, Hsien-Chang
影响因子：
26.1
作者：
Soneji S;Barrington-Trimis JL;Wills TA;Leventhal AM;Unger JB;Gibson LA;Yang J;Primack BA;Andrews JA;Miech RA;Spindle TR;Dick DM;Eissenberg T;Hornik RC;Dang R;Sargent JD
通讯作者：
Sargent JD
影响因子：
7.4
作者：
Graham AL;Cha S;Cobb NK;Fang Y;Niaura RS;Mushro A
通讯作者：
Mushro A