Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic Implications.
Fyn Signaling in Ischemia-Reperfusion Injury: Potential and Therapeutic Implications.
复制标题
DOI：
10.1155/2022/9112127
复制
发表时间：
2022
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
由动脉闭塞引起的缺血性中风是最常见的中风类型，是导致残疾和死亡的主要原因之一，发病率每年都在增加。Fyn是一种非受体酪氨酸激酶，属于Src激酶家族（SFKs），与神经系统的许多正常和病理过程有关，包括神经发育和疾病进展。近年来，越来越多的证据表明Fyn可能与脑缺血再灌注密切相关，包括能量代谢紊乱、兴奋性神经毒性、细胞内钙稳态、自由基产生、凋亡基因激活等。本文综述了Fyn在脑缺血-再灌注病理过程中的作用，包括神经兴奋毒性和神经炎症，探讨Fyn如何影响特异性信号级联并导致脑缺血-再灌注损伤。此外，Fyn还促进超氧化物和内源性NO的产生，从而快速反应产生过氧亚硝酸盐，也可能介导脑缺血再灌注损伤，本文对此进行了探讨。最后，我们揭示了Fyn抑制剂的相关治疗方法，并讨论了其作为缺血性脑卒中临床治疗的潜力。
Ischemic stroke caused by arterial occlusion is the most common type of stroke and is one of the leading causes of disability and death, with the incidence increasing each year. Fyn is a nonreceptor tyrosine kinase belonging to the Src family of kinases (SFKs), which is related to many normal and pathological processes of the nervous system, including neurodevelopment and disease progression. In recent years, more and more evidence suggests that Fyn may be closely related to cerebral ischemia-reperfusion, including energy metabolism disorders, excitatory neurotoxicity, intracellular calcium homeostasis, free radical production, and the activation of apoptotic genes. This paper reviews the role of Fyn in the pathological process of cerebral ischemia-reperfusion, including neuroexcitotoxicity and neuroinflammation, to explore how Fyn affects specific signal cascades and leads to cerebral ischemia-reperfusion injury. In addition, Fyn also promotes the production of superoxide and endogenous NO, so as to quickly react to produce peroxynitrite, which may also mediate cerebral ischemia-reperfusion injury, which is discussed in this paper. Finally, we revealed the treatment methods related to Fyn inhibitors and discussed its potential as a clinical treatment for ischemic stroke.
登录
查看更多内容
DOI：
10.4049/jimmunol.1102241
发表时间：
2012-06-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Ueda A;Zhou L;Stein PL
通讯作者：
Stein PL
影响因子：
5.3
作者：
Chen S;Shao L;Ma L
通讯作者：
Ma L
影响因子：
16.6
作者：
Giralt A;Brito V;Chevy Q;Simonnet C;Otsu Y;Cifuentes-Díaz C;de Pins B;Coura R;Alberch J;Ginés S;Poncer JC;Girault JA
通讯作者：
Girault JA
影响因子：
9.2
作者：
Erta M;Quintana A;Hidalgo J
通讯作者：
Hidalgo J
影响因子：
4.8
作者：
Bland, Tyler;Zhu, Mingyan;Wayman, Gary A.
通讯作者：
Wayman, Gary A.