World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia.

World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia.
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全球手指网络:降低痴呆症风险和预防的全球方法。

DOI:
10.1002/alz.12123
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发表时间:
2020-07
影响因子:
14
通讯作者:
Carrillo, Maria C.
Carrillo, Maria C.
中科院分区:
医学1区
文献类型:
--
作者:
Kivipelto, Miia;Mangialasche, Francesca;Snyder, Heather M.;Allegri, Ricardo;Andrieu, Sandrine;Arai, Hidenori;Baker, Laura;Belleville, Sylvie;Brodaty, Henry;Brucki, Sonia M.;Calandri, Ismael;Caramelli, Paulo;Chen, Christopher;Chertkow, Howard;Chew, Effie;Choi, Seong H.;Chowdhary, Neerja;Crivelli, Lucia;De La Torre, Rafael;Du, Yifeng;Dua, Tarun;Espeland, Mark;Feldman, Howard H.;Hartmanis, Maris;Hartmann, Tobias;Heffernan, Megan;Henry, Christiani J.;Hong, Chang H.;Hakansson, Krister;Iwatsubo, Takeshi;Jeong, Jee H.;Jimenez-Maggiora, Gustavo;Koo, Edward H.;Launer, Lenore J.;Lehtisalo, Jenni;Lopera, Francisco;Martinez-Lage, Pablo;Martins, Ralph;Middleton, Lefkos;Molinuevo, Jose L.;Montero-Odasso, Manuel;Moon, So Y.;Morales-Perez, Kristal;Nitrini, Ricardo;Nygaard, Haakon B.;Park, Yoo K.;Peltonen, Markku;Qiu, Chengxuan;Quiroz, Yakeel T.;Raman, Rema;Rao, Naren;Ravindranath, Vijayalakshmi;Rosenberg, Anna;Sakurai, Takashi;Salinas, Rosa M.;Scheltens, Philip;Sevlever, Gustavo;Soininen, Hilkka;Sosa, Ana L.;Suemoto, Claudia K.;Tainta-Cuezva, Mikel;Velilla, Lina;Wang, Yongxiang;Whitmer, Rachel;Xu, Xin;Bain, Lisa J.;Solomon, Alina;Ngandu, Tiia;Carrillo, Maria C.

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降低痴呆症的风险可以阻止全球受影响人口的增加。包括阿尔茨海默病(AD)在内的迟发性痴呆的多因素和异质性表明多领域生活方式干预对降低风险的潜在影响。具有里程碑意义的多领域芬兰预防认知障碍和残疾老年干预研究(FINGER)的积极结果支持这种方法。World-Wide FINGERS(WW-FINGERS)于2017年启动,涵盖超过25个国家,是首个针对痴呆症风险降低和预防的多领域生活方式干预试验的全球网络。WW-FINGERS旨在适应、测试和优化FINGER模型,以降低不同地理、文化和经济环境下认知能力下降的风险,从风险无症状状态到早期症状阶段。WW-FINGERS旨在协调和调整不同国家和环境的多领域干预措施,促进跨研究的数据共享和分析,并促进国际联合倡议,以确定全球可实施和有效的预防战略。
Reducing the risk of dementia can halt the worldwide increase of affected people. The multifactorial and heterogeneous nature of late-onset dementia, including Alzheimer’s disease (AD), indicates a potential impact of multidomain lifestyle interventions on risk reduction. The positive results of the landmark multidomain Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) support such an approach. The World-Wide FINGERS (WW-FINGERS), launched in 2017 and including over 25 countries, is the first global network of multidomain lifestyle intervention trials for dementia risk reduction and prevention. WW-FINGERS aims to adapt, test, and optimize the FINGER model to reduce risk across the spectrum of cognitive decline—from at-risk asymptomatic states to early symptomatic stages—in different geographical, cultural, and economic settings. WW-FINGERS aims to harmonize and adapt multidomain interventions across various countries and settings, to facilitate data sharing and analysis across studies, and to promote international joint initiatives to identify globally implementable and effective preventive strategies.
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