Changes in alcohol-related brain networks across the first year of college: a prospective pilot study using fMRI effective connectivity mapping.
Changes in alcohol-related brain networks across the first year of college: a prospective pilot study using fMRI effective connectivity mapping.
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DOI：
10.1016/j.addbeh.2012.12.023
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发表时间：
2013-04
影响因子：
4.4
通讯作者：
Wilson, Stephen J.
中科院分区：
文献类型：
--
作者：
Beltz, Adriene M.;Gates, Kathleen M.;Engels, Anna S.;Molenaar, Peter C. M.;Pulido, Carmen;Turrisi, Robert;Berenbaum, Sheri A.;Gilmore, Rick O.;Wilson, Stephen J.
在大学第一年期间经常出现的饮酒量激增现象，已被确凿地与许多负面的社会心理后果相关联，并且可能对大脑发育产生负面影响。在这项纵向功能性磁共振成像（fMRI）试点研究中，我们在一个正常的青少年晚期样本中，研究了大学第一年期间对酒精线索的神经反应变化。参与者（N = 11）在大学第一年期间接受了三次扫描（夏季、第一学期、第二学期），同时完成一项“做/不做”任务，其中含酒精和不含酒精饮料的图像是反应线索。一种最先进的有效连接映射技术被用于在群体和个体层面捕捉感兴趣脑区（ROIs）之间的时空关系。在第二次评估时（当饮酒的负面后果增加时），与认知控制有关的脑区之间的有效连接最强，并且当参与者被指示对酒精线索而非非酒精线索做出反应时，与情绪处理有关的脑区之间的有效连接更低（且反应时间更慢）。这些初步研究结果证明了前瞻性有效连接方法对于理解青少年与酒精相关的神经过程变化的价值。
The upsurge in alcohol use that often occurs during the first year of college has been convincingly linked to a number of negative psychosocial consequences and may negatively affect brain development. In this longitudinal functional magnetic resonance imaging (fMRI) pilot study, we examined changes in neural responses to alcohol cues across the first year of college in a normative sample of late adolescents. Participants (N=11) were scanned three times across their first year of college (summer, first semester, second semester), while completing a go/no-go task in which images of alcoholic and non-alcoholic beverages were the response cues. A state-of-the-art effective connectivity mapping technique was used to capture spatiotemporal relations among brain regions of interest (ROIs) at the level of the group and the individual. Effective connections among ROIs implicated in cognitive control were greatest at the second assessment (when negative consequences of alcohol use increased), and effective connections among ROIs implicated in emotion processing were lower (and response times were slower) when participants were instructed to respond to alcohol cues compared to non-alcohol cues. These preliminary findings demonstrate the value of a prospective effective connectivity approach for understanding adolescent changes in alcohol-related neural processes.
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影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
DOI：
10.1073/pnas.1121049109
发表时间：
2012-04-03
影响因子：
11.1
作者：
Gonzalez-Castillo, Javier;Saad, Ziad S.;Bandettini, Peter A.
通讯作者：
Bandettini, Peter A.
影响因子：
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作者：
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通讯作者：
Heller, Wendy
影响因子：
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作者：
Houben, Katrijn;Nederkoorn, Chantal;Jansen, Anita
通讯作者：
Jansen, Anita
影响因子：
2.3
作者：
Guerri, Consuelo;Pascual, Maria
通讯作者：
Pascual, Maria