Complex relationships of nicotinic receptor actions and cognitive functions.
Complex relationships of nicotinic receptor actions and cognitive functions.
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DOI：
10.1016/j.bcp.2013.07.021
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发表时间：
2013-10-15
影响因子：
5.8
通讯作者：
Levin, Edward D.
中科院分区：
文献类型：
--
作者：
Levin, Edward D.
尼古丁已被证明在各种研究，以改善认知功能，包括学习，记忆和注意力。尼古丁既能刺激烟碱受体又能使其脱敏，因此既能作为激动剂又能作为净拮抗剂。这两种作用对尼古丁诱导的认知改善的相对作用尚未完全确定。我们和其他人已经发现，急性烟碱拮抗剂治疗可以改善学习和注意力。尼古丁作用于多种烟碱受体亚型。神经元烟碱受体亚型对认知的相对作用和相互作用也需要更好地表征。尼古丁作用于多种大脑区域的烟碱受体。这些区域中的一些区域如海马的作用已经得到了相对较好的研究，但其他区域如丘脑，其具有降血糖烟碱受体浓度仍然只是部分特征。在一系列研究中，我们表征了烟碱受体作用、解剖定位和回路相互作用，这对尼古丁对学习、记忆和注意力的认知功能的影响至关重要。在局部输注烟碱受体亚型（α7和α4β2）拮抗剂的海马、杏仁核、额叶皮质和丘脑背内侧核的区域特异性研究中，确定了尼古丁对烟碱受体激活的增加和减少的相对作用。认知功能的功能性神经基础的理解是更有效地开发用于治疗认知功能障碍的烟碱类药物的基础。
Nicotine has been shown in a variety of studies to improve cognitive function including learning, memory and attention. Nicotine both stimulates and desensitizes nicotinic receptors, thus acting both as an agonist and a net antagonist. The relative roles of these two actions for nicotine-induced cognitive improvement have not yet been fully determined. We and others have found that acute nicotinic antagonist treatment can improve learning and attention. Nicotine acts on a variety of nicotinic receptor subtypes. The relative role and interactions of neuronal nicotinic receptor subtypes for cognition also needs to be better characterized. Nicotine acts on nicotinic receptors in a wide variety of brain areas. The role of some of these areas such as the hippocampus has been relatively well studied but other area like the thalamus, which has the densest nicotinic receptor concentration are still only partially characterized. In a series of studies we characterized nicotinic receptor actions, anatomic localization and circuit interactions, which are critical to nicotine effects on the cognitive functions of learning, memory and attention. The relative role of increases and decreases in nicotinic receptor activation by nicotine were determined in regionally specific studies of the hippocampus, the amygdala, the frontal cortex and the mediodorsal thalamic nucleus with local infusions of antagonists of nicotinic receptor subtypes (α7 and α4β2). The understanding of the functional neural bases of cognitive function is fundamental to the more effective development of nicotinic drugs for treating cognitive dysfunction.
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影响因子：
3.4
作者：
Arthur, D;Levin, ED
通讯作者：
Levin, ED
影响因子：
3.4
作者：
Heishman, Stephen J.;Kleykamp, Bethea A.;Singleton, Edward G.
通讯作者：
Singleton, Edward G.
影响因子：
5.7
作者：
Kumari, V;Gray, JA;Sharma, T
通讯作者：
Sharma, T
DOI：
10.1124/jpet.108.145292
发表时间：
2009-02-01
影响因子：
3.5
作者：
Buccafusco, Jerry J.;Beach, J. Warren;Terry, Alvin V., Jr.
通讯作者：
Terry, Alvin V., Jr.
影响因子：
2.9
作者：
LEVIN, ED;BRIGGS, SJ;AUMAN, JT
通讯作者：
AUMAN, JT