Detection of the antiviral drug oseltamivir in aquatic environments.
Detection of the antiviral drug oseltamivir in aquatic environments.
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水生环境中抗病毒药物奥司他韦的检测。
DOI：
10.1371/journal.pone.0006064
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发表时间：
2009-06-26
期刊：
影响因子：
3.7
通讯作者：
Fick, Jerker
中科院分区：
文献类型：
--
作者：
Soderstrom, Hanna;Jarhult, Josef D.;Olsen, Bjorn;Lindberg, Richard H.;Tanaka, Hiroaki;Fick, Jerker
奥司他韦（达菲®）是目前最重要的抗病毒药物，也是预防未来流感大流行的基石。最近的出版物表明，活性代谢物奥司他韦羧酸盐（OC）在污水处理厂中不会降解，在水生环境中也具有持久性。这意味着OC将存在于奥司他韦处方给患者用于治疗的区域的水生环境中。奥司他韦使用最多的国家是日本，在那里它被用来治疗季节性流感。我们测量了2007/8年流感季节之前和期间日本京都和大坂府淀川水系水样中的OC水平。在流感季节之前没有检测到OC，但在流感季节期间采集的样本中检测到2-58 ng L−1。这项研究首次表明，在水生环境中可以发现低水平的奥司他韦。因此，流感病毒的天然储存库，鸭子，暴露于奥司他韦，这可能会促进病毒耐药性的进化。
Oseltamivir (Tamiflu®) is the most important antiviral drug available and a cornerstone in the defence against a future influenza pandemic. Recent publications have shown that the active metabolite, oseltamivir carboxylate (OC), is not degraded in sewage treatment plants and is also persistent in aquatic environments. This implies that OC will be present in aquatic environments in areas where oseltamivir is prescribed to patients for therapeutic use. The country where oseltamivir is used most is Japan, where it is used to treat seasonal flu. We measured the levels of OC in water samples from the Yodo River system in the Kyoto and Osaka prefectures, Japan, taken before and during the flu-season 2007/8. No OC was detected before the flu-season but 2–58 ng L−1 was detected in the samples taken during the flu season. This study shows, for the first time, that low levels of oseltamivir can be found in the aquatic environment. Therefore the natural reservoir of influenza virus, dabbling ducks, is exposed to oseltamivir, which could promote the evolution of viral resistance.
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