Signals that drive T-bet expression in B cells.
Signals that drive T-bet expression in B cells.
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DOI：
10.1016/j.cellimm.2017.09.004
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发表时间：
2017-11
影响因子：
4.3
通讯作者：
Cancro MP
中科院分区：
文献类型：
--
作者：
Myles A;Gearhart PJ;Cancro MP
转录因子调节B细胞的各种发育和功能方面。T-bet是一种最近发现的转录因子，与“淋巴细胞相关的B细胞”或ABC、自身免疫的发展和病毒感染相关。T-bet表达受含核酸抗原和免疫复合物的支持，并受各种细胞因子（特别是TFH细胞因子IL-21、IL-4和IFNγ）之间的相互作用调节。自适应信号本身不能上调T-bet;然而，它们对先天受体诱导T-bet具有协同作用。T-bet + B细胞的功能作用尚不清楚，尽管已知T-bet促进向IgG 2a/c的类别转换。T-bet可能在B细胞中起着双重作用，一方面促进致病性自身反应性抗体，另一方面介导微生物免疫，使其成为治疗和预防环境中的目标。
Transcription factors regulate various developmental and functional aspects of B cells. T-bet is a recently appreciated transcription factor associated with “Age-associated B cells” or ABCs, the development of autoimmunity, and viral infections. T-bet expression is favored by nucleic acid-containing antigens and immune complexes and is regulated by interplay between various cytokines, notably, the TFH cytokines IL-21, IL-4 and IFNγ. Adaptive signals by themselves cannot upregulate T-bet; however, they have a synergistic effect on induction of T-bet by innate receptors. The functional role of T-bet + B cells is unclear, although it is known that T-bet promotes class switching to IgG2a/c. It is likely T-bet serves dichotomous roles in B cells, promoting pathogenic autoreactive antibodies on one hand but mediating microbial immunity on the other, making it a target of interest in both therapeutic and prophylactic settings.
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