ALDH1 expression correlates with favorable prognosis in ovarian cancers.
ALDH1 expression correlates with favorable prognosis in ovarian cancers.
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DOI：
10.1038/modpathol.2009.35
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发表时间：
2009-06
期刊：
影响因子：
--
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中科院分区：
文献类型：
--
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醛脱氢酶1（ALDH 1）是一种负责细胞内醛氧化的解毒酶，通过其将视黄醇氧化为视黄酸的作用，在干细胞的早期分化中发挥作用。已经表明，ALDH1是乳腺癌临床结果差的预测因子。作者推测ALDH1表达水平可能与卵巢癌患者的临床结局相关。应用组织芯片技术对442例原发性卵巢癌组织中ALDH 1的表达进行了免疫组化分析。分析ALDH1表达与临床因素（诊断、肿瘤分级、分期和对化疗的临床反应）以及总体和无病生存期之间的相关性。ALDH1的表达率为48.9%。Fisher精确检验显示ALDH 1的高表达与卵巢样腺癌（P < 0.0001）、疾病早期（P = 0.006）、化疗完全缓解（P <0.05）和低血清CA 125水平（P = 0.02）显著相关。对数秩检验显示，高百分比的表达ALDH1的细胞与较长的总生存时间（P =0.01）和无病生存时间（P = 0.006）相关。与其在乳腺癌中的作用相反，ALDH 1是卵巢癌的有利预后因子。因此，ALDH1在卵巢癌中的作用可能与乳腺癌不同。
Aldehyde dehydrogenase 1 (ALDH1), a detoxifying enzyme responsible for the oxidation of intracellular aldehydes, was shown to play a role in the early differentiation of stem cells, through its role in oxidizing retinol to retinoic acid. It has been shown that ALDH1 is a predictor of poor clinical outcome in breast cancer. The authors hypothesized that the level of ALDH1 expression may be correlated with the clinical outcome of patients with ovarian cancer. Immunohistochemical staining of ALDH1 expression was analyzed in 442 primary ovarian carcinomas using tissue microarray. The associations between the expression of the ALDH1 and clinical factors (diagnosis, tumor grade, stage, and clinical response to chemotherapy), as well overall and disease-free survival were analyzed. Expression of ALDH1 was found in 48.9% of the samples. Fisher's exact test suggested that high expression of ALDH1 was significantly associated with endometrioid adenocarcinoma (P < 0.0001), early-stage disease (P = 0.006), complete response to chemotherapy (P <0.05) and a low serum level of CA125 (P = 0.02). High percentage of cells expressing ALDH1 was associated with a longer overall survival time (P =0.01) and disease free survival time (P = 0.006) by Log rank test. In contrast to its role in breast cancer, ALDH1 was a favorable prognostic factor in ovarian carcinoma. ALDH1 therefore may play a different role in ovarian cancer than it does in breast cancer.
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DOI：
10.1186/bcr1673
发表时间：
2007
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Fillmore C;Kuperwasser C
通讯作者：
Kuperwasser C
影响因子：
6.2
作者：
Rosen, DG;Yang, G;Liu, JS
通讯作者：
Liu, JS
影响因子：
5.1
作者：
Duester, G;Mic, FA;Molotkov, A
通讯作者：
Molotkov, A
影响因子：
5.2
作者：
Ma, Stephanie;Chan, Kwok Wah;Guan, Xin-Yuan
通讯作者：
Guan, Xin-Yuan
影响因子：
4.5
作者：
RUSSELL, P
通讯作者：
RUSSELL, P