The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population.
The regulation of the homeostasis and regeneration of peripheral nerve is distinct from the CNS and independent of a stem cell population.
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周围神经的稳态和再生的调节不同于中枢神经系统并且独立于干细胞群。
DOI：
10.1242/dev.170316
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发表时间：
2018-12-14
期刊：
影响因子：
--
通讯作者：
Lloyd AC
中科院分区：
文献类型：
--
作者：
Stierli S;Napoli I;White IJ;Cattin AL;Monteza Cabrejos A;Garcia Calavia N;Malong L;Ribeiro S;Nihouarn J;Williams R;Young KM;Richardson WD;Lloyd AC
与中枢神经系统（CNS）的再生能力较差相比，周围神经具有高度再生能力。在这里，我们表明，成人周围神经是比中枢神经系统更加静止的组织，但周围神经内的所有细胞类型在受伤后都能有效增殖。此外，虽然少突胶质细胞在整个生命过程中都是由前体池产生的，但我们发现周围神经系统的相应细胞，髓鞘雪旺细胞（mSC），在成人中不会更新。然而，受伤后，所有 mSC 都可以去分化为增殖性祖细胞样雪旺细胞 (SC)，从而协调再生反应。谱系分析表明，这些新迁移的类祖细胞重新分化，在损伤部位形成新组织并维持其谱系，但可以转变为非髓鞘 SC。相反，在肿瘤发生过程中观察到可塑性增加。这些发现表明，周围神经具有维持体内平衡的独特机制，并且无需额外的干细胞群即可再生。 谱系分析和长期标记研究表明，周围神经再生是由成熟细胞的增殖可塑性而不是干细胞群的激活支撑的。
Peripheral nerves are highly regenerative, in contrast to the poor regenerative capabilities of the central nervous system (CNS). Here, we show that adult peripheral nerve is a more quiescent tissue than the CNS, yet all cell types within a peripheral nerve proliferate efficiently following injury. Moreover, whereas oligodendrocytes are produced throughout life from a precursor pool, we find that the corresponding cell of the peripheral nervous system, the myelinating Schwann cell (mSC), does not turn over in the adult. However, following injury, all mSCs can dedifferentiate to the proliferating progenitor-like Schwann cells (SCs) that orchestrate the regenerative response. Lineage analysis shows that these newly migratory, progenitor-like cells redifferentiate to form new tissue at the injury site and maintain their lineage, but can switch to become a non-myelinating SC. In contrast, increased plasticity is observed during tumourigenesis. These findings show that peripheral nerves have a distinct mechanism for maintaining homeostasis and can regenerate without the need for an additional stem cell population. Lineage analysis and long-term labelling studies show that peripheral nerve regeneration is underpinned by the proliferative plasticity of mature cells rather than the activation of a stem cell population.
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影响因子：
16.2
作者：
Kang, Shin H.;Fukaya, Masahiro;Yang, Jason K.;Rothstein, Jeffrey D.;Bergles, Dwight E.
通讯作者：
Bergles, Dwight E.
DOI：
10.1083/jcb.201205025
发表时间：
2012-07-09
期刊：
The Journal of cell biology
影响因子：
--
作者：
Fontana X;Hristova M;Da Costa C;Patodia S;Thei L;Makwana M;Spencer-Dene B;Latouche M;Mirsky R;Jessen KR;Klein R;Raivich G;Behrens A
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影响因子：
8.8
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Askew K;Li K;Olmos-Alonso A;Garcia-Moreno F;Liang Y;Richardson P;Tipton T;Chapman MA;Riecken K;Beccari S;Sierra A;Molnár Z;Cragg MS;Garaschuk O;Perry VH;Gomez-Nicola D
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Gomez-Nicola D
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影响因子：
5.7
作者：
Birey F;Kokkosis AG;Aguirre A
通讯作者：
Aguirre A
影响因子：
23.9
作者：
Guimarães-Camboa N;Cattaneo P;Sun Y;Moore-Morris T;Gu Y;Dalton ND;Rockenstein E;Masliah E;Peterson KL;Stallcup WB;Chen J;Evans SM
通讯作者：
Evans SM