A G4-DNA/B-DNA junction at codon 12 of c-Ha-ras is actively and asymmetrically methylated by DNA(cytosine-5)methyltransferase.
A G4-DNA/B-DNA junction at codon 12 of c-Ha-ras is actively and asymmetrically methylated by DNA(cytosine-5)methyltransferase.
复制标题
c-Ha-ras 密码子 12 处的 G4-DNA/B-DNA 连接点被 DNA(胞嘧啶-5)甲基转移酶主动且不对称地甲基化。
DOI：
10.1016/s0006-291x(89)80159-7
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发表时间：
1989
影响因子：
3.1
通讯作者：
Jardines,LA
中科院分区：
文献类型：
--
作者：
Smith,SS;Baker,DJ;Jardines,LA
Oligodeoxynucleotides spanning codon 12 of the human c-Ha-rasgene were found to be exceptionally good substrates forde novomethylation by human DNA(cytosine-5)methyltransferase. In the complex formed by two complementary 30mers, only the C-rich strand was methylated by the enzyme. Guanines at the 3′ end of the G-rich strand of the complex could not be completely modified by dimethylsulfoxide suggesting tetrameric bonding at these G-residues. An eight-stranded structure, composed of four duplex DNAs at one end, joined to a G4-DNA segment at the other with the junction between the two DNA forms at codon 12, can account for our results.
通过人类 DNA(胞嘧啶-5)甲基转移酶识别 DNA 中的结构扰动。
影响因子：
3.5
作者：
D. Baker;J. Kan;S. S. Smith
通讯作者：
S. S. Smith
影响因子：
14.9
作者：
SINHA, ND;BIERNAT, J;KOSTER, H
通讯作者：
KOSTER, H