Altered development of the dorsolateral prefrontal cortex in chromosome 22q11.2 deletion syndrome: an in vivo proton spectroscopy study.
Altered development of the dorsolateral prefrontal cortex in chromosome 22q11.2 deletion syndrome: an in vivo proton spectroscopy study.
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DOI：
10.1016/j.biopsych.2012.04.023
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发表时间：
2012-10-15
影响因子：
10.6
通讯作者：
Stanley JA
中科院分区：
文献类型：
--
作者：
Shashi V;Veerapandiyan A;Keshavan MS;Zapadka M;Schoch K;Kwapil TR;Hooper SR;Stanley JA
Chromosome 22q11.2 deletion syndrome (22q11DS), the most common microdeletion in humans, is associated with multiple medical features, almost universal cognitive deficits, and a high-risk of schizophrenia. The metabolic basis of the psychological/psychiatric features is not well understood. Volumetric brain imaging studies have shown that gray matter abnormalities in the dorsolateral prefrontal cortex (DLPFC), an area that is believed to be integral for higher neurocognition, as well as being involved in schizophrenia, are associated with the psychological manifestations. However, studies have not characterized any possible metabolite alterations within the DLPFC of children with 22q11DS and their correlations with the psychological findings. We conducted a short echo-time, single-voxel, in vivo 1H spectroscopy study involving children with 22q11DS (n=26) and matched control subjects (n=23). Absolute N-acetyl-aspartate (NAA) levels from the DLPFC were significantly elevated in children with 22q11DS compared to control subjects and the elevations were associated with poor global functioning and higher rates of comorbid attention deficit hyperactivity disorder. Children with 22q11DS had a lack of an age-associated decrease in NAA levels, a trend seen in the control subjects. However, the results did not remain statistically significant after corrections for multiple comparisons were made. These findings represent the first report of 1H spectroscopy in children with 22q11DS. The elevated DLPFC NAA levels and the lack of decreasing trends in NAA with age in the 22q11DS group relative to controls suggest an alteration in cortical development. Also, such neuronal dysmaturation is associated with psychopathology in children with 22q11DS.
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DOI：
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发表时间：
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影响因子：
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