Sirtuins and Accelerated Aging in Scleroderma.
Sirtuins and Accelerated Aging in Scleroderma.
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DOI：
10.1007/s11926-018-0724-6
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发表时间：
2018-03-17
影响因子：
5
通讯作者：
Atamas SP
中科院分区：
文献类型：
--
作者：
Wyman AE;Atamas SP
衰老相关分子机制的过早激活正在成为许多疾病的重要因素，包括硬皮病。在衰老过程的中央调节因素中，有一组称为sirtuins(Sirtuins)的组蛋白脱乙酰酶。最近的发现表明，这些分子在硬皮病皮肤和肺纤维化中起着病理生理作用。本文的目的是从衰老相关分子机制的角度综述SIRT参与硬皮病的最新研究。尽管在这个迅速发展的领域存在一定程度的争议，但大多数数据表明，与健康对照组和硬皮病动物模型相比，硬皮病患者组织中的SIRT水平降低。分子研究揭示了SIRT水平下降导致纤维化的几种机制，其中最受关注的是对转化生长因子-β信号通路的调控。在细胞培养和动物模型中激活SIRT可产生抗纤维化作用。SIRT水平和活性的下降正在成为硬皮病的病理生理因素。SIRT的恢复可能对硬皮病患者有治疗作用。
Premature activation of aging-associated molecular mechanisms is emerging as an important contributor to many diseases, including scleroderma. Among central regulators of the aging process are a group of histone deacetylases called sirtuins (SIRTs). Recent findings implicate these molecules as pathophysiological players in scleroderma skin and lung fibrosis. The goal of this article is to review recent studies on the involvement of SIRTs in scleroderma from the perspective of aging-related molecular mechanisms. Despite a degree of controversy in this rapidly developing field, the majority of data suggest that SIRT levels are decreased in tissues from patients with scleroderma compared to healthy controls as well as in animal models of scleroderma. Molecular studies reveal several mechanisms through which declining SIRT levels contribute to fibrosis, with the most attention given to modulation of the TGF-β signaling pathway. Activation of SIRTs in cell culture and in animal models elicits antifibrotic effects. Declining SIRT levels and activity are emerging as pathophysiological contributors to scleroderma. Restoration of SIRTs may be therapeutic in patients with scleroderma.
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影响因子：
--
作者：
Albani, Diego;Ateri, Eleonora;Forloni, Gianluigi
通讯作者：
Forloni, Gianluigi
影响因子：
4.3
作者：
Deschenes-Simard, Xavier;Lessard, Frederic;Ferbeyre, Gerardo
通讯作者：
Ferbeyre, Gerardo
影响因子：
4
作者：
Hajialilo, Mehrzad;Noorabadi, Parisa;Mahdavi, Aida Malek
通讯作者：
Mahdavi, Aida Malek
影响因子：
--
作者：
Akamata K;Wei J;Bhattacharyya M;Cheresh P;Bonner MY;Arbiser JL;Raparia K;Gupta MP;Kamp DW;Varga J
通讯作者：
Varga J
影响因子：
64.5
作者：
Chang HC;Guarente L
通讯作者：
Guarente L