Plant Copper Metalloenzymes As Prospects for New Metabolism Involving Aromatic Compounds.
Plant Copper Metalloenzymes As Prospects for New Metabolism Involving Aromatic Compounds.
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DOI：
10.3389/fpls.2021.692108
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发表时间：
2021
影响因子：
5.6
通讯作者：
Kersten RD
中科院分区：
文献类型：
--
作者：
Mydy LS;Chigumba DN;Kersten RD
铜是植物代谢中重要的过渡金属辅因子，在有氧环境中能够进行多种生物催化。植物金属酶的多个类别的演变，并在陆生植物的进化过程中经历了遗传扩张，到目前为止，这些铜酶类的几个代表的特点机制。本文综述了植物铜金属酶的化学组成、结构、作用机制、功能和系统发育分布，重点介绍了芳香族化合物如苯丙素类化合物（木质素、木脂素、黄酮类化合物）和芳香族氨基酸大环化环肽的生物合成。我们还审查了最近除了植物铜酶学铜依赖性肽环化酶称为BURP域。鉴于植物遗传资源的不断增长，大量的铜生物催化剂仍有待于从植物中鉴定，因为植物基因组平均含有70多个铜酶基因。植物基因组中铜生物催化剂表征的一个主要挑战是内源底物和催化反应的鉴定。我们强调了一些最近和未来的趋势，填补这些知识空白，植物代谢和潜在的基因组发现铜为基础的酶学从植物。
Copper is an important transition metal cofactor in plant metabolism, which enables diverse biocatalysis in aerobic environments. Multiple classes of plant metalloenzymes evolved and underwent genetic expansions during the evolution of terrestrial plants and, to date, several representatives of these copper enzyme classes have characterized mechanisms. In this review, we give an updated overview of chemistry, structure, mechanism, function and phylogenetic distribution of plant copper metalloenzymes with an emphasis on biosynthesis of aromatic compounds such as phenylpropanoids (lignin, lignan, flavonoids) and cyclic peptides with macrocyclizations via aromatic amino acids. We also review a recent addition to plant copper enzymology in a copper-dependent peptide cyclase called the BURP domain. Given growing plant genetic resources, a large pool of copper biocatalysts remains to be characterized from plants as plant genomes contain on average more than 70 copper enzyme genes. A major challenge in characterization of copper biocatalysts from plant genomes is the identification of endogenous substrates and catalyzed reactions. We highlight some recent and future trends in filling these knowledge gaps in plant metabolism and the potential for genomic discovery of copper-based enzymology from plants.
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影响因子：
11.9
作者：
Beniddir MA;Kang KB;Genta-Jouve G;Huber F;Rogers S;van der Hooft JJJ
通讯作者：
van der Hooft JJJ
影响因子：
4.8
作者：
Bienert, Gerd P.;Moller, Anders L. B.;Jahn, Thomas P.
通讯作者：
Jahn, Thomas P.
影响因子：
5.2
作者：
Caparros-Ruiz, David;Fornale, Silvia;Rigau, Joan
通讯作者：
Rigau, Joan
影响因子：
3.7
作者：
Cheng, Xi;Li, Guohui;Lin, Yi
通讯作者：
Lin, Yi
棉中多功能漆酶基因家族的全基因组鉴定（Gossypium spp。）；纤维发育过程中的表达和生化分析。
影响因子：
4.6
作者：
Balasubramanian VK;Rai KM;Thu SW;Hii MM;Mendu V
通讯作者：
Mendu V