Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway.
Inorganic nitrate promotes the browning of white adipose tissue through the nitrate-nitrite-nitric oxide pathway.
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DOI：
10.2337/db14-0496
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发表时间：
2015-02
期刊：
影响因子：
7.7
通讯作者：
Griffin JL
中科院分区：
文献类型：
--
作者：
Roberts LD;Ashmore T;Kotwica AO;Murfitt SA;Fernandez BO;Feelisch M;Murray AJ;Griffin JL
Inorganic nitrate was once considered an oxidation end-product of nitric oxide metabolism with little biological activity. However, recent studies have demonstrated that dietary nitrate can modulate mitochondrial function in man and is effective in reversing features of the metabolic syndrome in mice. Using a combined histological, metabolomics, and transcriptional and protein analysis approach we mechanistically define that nitrate not only increases the expression of thermogenic genes in brown-adipose tissue but also induces the expression of brown adipocyte-specific genes and proteins in white adipose tissue, substantially increasing oxygen consumption and fatty acid β-oxidation in adipocytes. Nitrate induces these phenotypic changes through a mechanism distinct from known physiological small molecule activators of browning, the recently identified nitrate-nitrite-nitric oxide pathway. The nitrate-induced browning effect was enhanced in hypoxia, a serious co-morbidity affecting white adipose tissue in obese individuals, and corrected impaired brown adipocyte-specific gene expression in white adipose tissue in a murine model of obesity. Since resulting beige/brite cells exhibit anti-obesity and anti-diabetic effects, nitrate may be an effective means of inducing the browning response in adipose tissue to treat the metabolic syndrome.
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DOI：
10.1126/science.1190816
发表时间：
2010-05-28
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ishibashi J;Seale P
通讯作者：
Seale P
影响因子：
8.3
作者：
Kapil, Vikas;Milsom, Alexandra B.;Ahluwalia, Amrita
通讯作者：
Ahluwalia, Amrita
DOI：
10.1073/pnas.1008872107
发表时间：
2010-10-12
影响因子：
11.1
作者：
Carlstrom, Mattias;Larsen, Filip J.;Lundberg, Jon O.
通讯作者：
Lundberg, Jon O.
影响因子：
64.8
作者：
Enerback, S;Jacobsson, A;Kozak, LP
通讯作者：
Kozak, LP
影响因子：
4.8
作者：
Mitschke, Michaela M.;Hoffmann, Linda S.;Kilic, Ana
通讯作者：
Kilic, Ana