Local and Systemic Effects of Porphyromonas gingivalis Infection.
Local and Systemic Effects of Porphyromonas gingivalis Infection.
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DOI：
10.3390/microorganisms11020470
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发表时间：
2023-02-13
期刊：
影响因子：
4.5
通讯作者：
Boskovic, Danilo S.
中科院分区：
文献类型：
--
作者：
Chen, William A.;Dou, Yuetan;Fletcher, Hansel M.;Boskovic, Danilo S.
Porphyromonas gingivalis, a gram-negative anaerobe, is a leading etiological agent in periodontitis. This infectious pathogen can induce a dysbiotic, proinflammatory state within the oral cavity by disrupting commensal interactions between the host and oral microbiota. It is advantageous for P. gingivalis to avoid complete host immunosuppression, as inflammation-induced tissue damage provides essential nutrients necessary for robust bacterial proliferation. In this context, P. gingivalis can gain access to the systemic circulation, where it can promote a prothrombotic state. P. gingivalis expresses a number of virulence factors, which aid this pathogen toward infection of a variety of host cells, evasion of detection by the host immune system, subversion of the host immune responses, and activation of several humoral and cellular hemostatic factors.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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