Case Detection Testing for Primary Aldosteronism in Male Patients with Hypertension and Snoring
Case Detection Testing for Primary Aldosteronism in Male Patients with Hypertension and Snoring
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男性高血压和打鼾患者原发性醛固酮增多症的病例检测
DOI：
10.4172/2167-1095.1000180
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发表时间：
2014-10
影响因子：
4.9
通讯作者：
Xiangyang Zhang
中科院分区：
文献类型：
--
作者：
Menghui Wang;Nanfang Li;Ying Zhang;Delian Zhang;Suofeiya Abulikemu;Yinchun Wang;Guli Nuer;Jianqiong Kong;Juhong Zhang;Zhitao Yan;Hongjian Li;Xiangyang Zhang
目的：原发性醛固酮增多症和阻塞性睡眠呼吸暂停在高血压病中并存。然而，在顽固性高血压患者中，醛固酮和肾素活性随呼吸暂停/低通气指数的变化而变化。因此，目的是探讨醛固酮/肾素活性筛选原发性醛固酮增多症患者的不同状态的呼吸暂停/低通气指数的可选截止值。
研究方法：对271例男性高血压打鼾者进行多导睡眠监测，并将其分为两组，呼吸暂停/低通气指数>15次/h组和呼吸暂停/低通气指数> 15 ng/dL组行生理盐水输注试验，以醛固酮浓度>5 ng/dL为原发性醛固酮增多症的标志。应用受试者工作特征曲线（ROC曲线）探讨醛固酮/肾素活性的临界值。
结果：39例（14.4%）诊断为原发性醛固酮增多症，其中15例呼吸暂停/低通气指数> 15次/h。呼吸暂停/低通气指数>15次/h组的受试者工作特征曲线下面积为0.97（95%CI 0.94-0.99），呼吸暂停/低通气指数15次/h组的受试者工作特征曲线下面积为0.91（95%CI 0.87-0.96），敏感性为100%，特异性为69.7%。对于呼吸暂停/低通气指数15次/h的组，约登指数为0.9。
结论：在不同呼吸暂停/低通气指数状态的患者中，应考虑筛选原发性醛固酮增多症的可选醛固酮/肾素活性临界值。
Objectives: Coexistence of primary aldosteronism and obstructive sleep apnea in hypertension is evidenced. However, aldosterone and renin activity is varying with apnea/hypopnea index changes in subjects with resistant hypertension. Thus, the aim is to investigate the optional cutoff value for aldosterone/renin activity to screen primary aldosteronism in patients with different status of apnea/hypopnea index.
Methods: 271 hypertensive male snores were evaluated via polysomnography and divided into two groups, group with apnea/hypopnea index >15 events/h and with apnea/hypopnea index 15 ng/dL performed saline infusion test, after which aldosterone concentration>5 ng/dL was a sign of primary aldosteronism. Receiver operating characteristic curve was applied to explore appropriate cutoff value for aldosterone/renin activity.
Results: 39 (14.4%) of the 271 were diagnosed with primary aldosteronism including 15 with apnea/hypopnea index 15 events/h. Area under receiver operating characteristic curve was 0.97 (95%CI 0.94-0.99) in the group with apnea/hypopnea index >15 events/h and 0.91 (95%CI 0.87-0.96) in the group with apnea/hypopnea index 15 events/h with sensitivity 100%, specificity 69.7%. Youden index is 0.9 for the group with apnea/hypopnea index 15 events/h.
Conclusions: Optional cutoff values of aldosterone/renin activity to screening for primary aldosteronism should be considered in patients with different status of apnea/hypopnea index.
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睡眠呼吸暂停和夜间心律不齐：人口研究。
影响因子：
2.6
作者：
Cintra FD;Leite RP;Storti LJ;Bittencourt LA;Poyares D;Castro LD;Tufik S;Paola AD
通讯作者：
Paola AD
影响因子：
9.6
作者：
Bucca, Caterina B.;Brussino, Luisa;Cicolin, Alessandro
通讯作者：
Cicolin, Alessandro
影响因子：
9.6
作者：
Calhoun, DA;Nishizaka, MK;Harding, SM
通讯作者：
Harding, SM
DOI：
10.1152/ajpregu.1988.254.3.r431
发表时间：
1988-03
期刊：
The American journal of physiology
影响因子：
--
作者：
H. Raff;T. Roarty
通讯作者：
H. Raff;T. Roarty
影响因子：
8.3
作者：
I. Armando;Xiaoyan Wang;V. Villar;J. Jones;L. Asico;P. Jose
通讯作者：
I. Armando;Xiaoyan Wang;V. Villar;J. Jones;L. Asico;P. Jose