Selective cancer cell killing by alpha-tocopheryl succinate.

Selective cancer cell killing by alpha-tocopheryl succinate.
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DOI:
10.1054/bjoc.2000.1559
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发表时间:
2001-01-05
影响因子:
8.8
通讯作者:
Weber C
Weber C
中科院分区:
医学1区
文献类型:
--
作者:
Neuzil J;Weber T;Gellert N;Weber C

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我们报告说,α-生育酚琥珀酸酯是一种具有促凋亡特性的维生素 E 类似物,可选择性杀死具有恶性或转化表型的细胞(即多种造血细胞和癌细胞系),同时对正常细胞(即原代细胞和非转化细胞)无毒。这些发现强烈表明这种微量营养素在治疗和/或预防癌症方面具有潜力,且没有明显的副作用。 © 2001 癌症研究运动 http://www.bjcancer.com
We report that α-tocopheryl succinate, a vitamin E analogue with pro-apoptotic properties, selectively kills cells with a malignant or transformed phenotype, i.e. multiple haematopoietic and carcinoma cell lines, while being non-toxic to normal, i.e. primary and non-transformed cells. These findings strongly suggest a potential of this micronutrient in the therapy and/or prevention of cancer without significant side-effects. © 2001 Cancer Research Campaign http://www.bjcancer.com
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