Aberrant hippocampal subregion networks associated with the classifications of aMCI subjects: a longitudinal resting-state study.
Aberrant hippocampal subregion networks associated with the classifications of aMCI subjects: a longitudinal resting-state study.
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DOI：
10.1371/journal.pone.0029288
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Bai F;Xie C;Watson DR;Shi Y;Yuan Y;Wang Y;Yue C;Teng Y;Wu D;Zhang Z
海马结构和功能的改变是可能从遗忘型轻度认知障碍（aMCI）转变为阿尔茨海默病（AD）的一个有价值的指标。然而，对于aMCI受试者海马次区域网络的功能连通性的破坏知之甚少。aMCI组1 （n = 26）和对照组1 （n = 18）进行了基线和大约20个月后的静息状态fMRI扫描。随后，随着时间的推移，研究人员探索了包含六个海马亚区（即锥体、齿状回和侧侧的水下复合体）的分布式功能连接网络的完整性，并进行了组间比较。进一步评估30名受试者（aMCI-转换组，n = 6； aMCI- 2组，n = 12；对照组-2组，n = 12）的这些程度纵向变化能力。aMCI受试者海马纵向分区域功能连接网络随时间的变化相似，主要与额回内侧、颞叶外侧、脑岛、后扣带皮层和小脑相关。然而，海马亚区和PCC的分离可能是aMCI情景记忆受损的关键因素，这些纵向变化的功能指数可以很好地区分aMCI转换者和非转换者（敏感性为83.3%，特异性为83.3%）和对照组（敏感性为83.3%，特异性为91.7%）的独立样本。这表明静息状态海马次区域网络的功能变化可能是功能障碍的重要早期指标，可能与aMCI受试者的早期变化和进展特别相关。
Altered hippocampal structure and function is a valuable indicator of possible conversion from amnestic type mild cognitive impairment (aMCI) to Alzheimer's disease (AD). However, little is known about the disrupted functional connectivity of hippocampus subregional networks in aMCI subjects. aMCI group-1 (n = 26) and controls group-1 (n = 18) underwent baseline and after approximately 20 months follow up resting-state fMRI scans. Integrity of distributed functional connectivity networks incorporating six hippocampal subregions (i.e. cornu ammonis, dentate gyrus and subicular complex, bilaterally) was then explored over time and comparisons made between groups. The ability of these extent longitudinal changes to separate unrelated groups of 30 subjects (aMCI-converters, n = 6; aMCI group-2, n = 12; controls group-2, n = 12) were further assessed. Six longitudinal hippocampus subregional functional connectivity networks showed similar changes in aMCI subjects over time, which were mainly associated with medial frontal gyrus, lateral temporal cortex, insula, posterior cingulate cortex (PCC) and cerebellum. However, the disconnection of hippocampal subregions and PCC may be a key factor of impaired episodic memory in aMCI, and the functional index of these longitudinal changes allowed well classifying independent samples of aMCI converters from non-converters (sensitivity was 83.3%, specificity was 83.3%) and controls (sensitivity was 83.3%, specificity was 91.7%). It demonstrated that the functional changes in resting-state hippocampus subregional networks could be an important and early indicator for dysfunction that may be particularly relevant to early stage changes and progression of aMCI subjects.
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影响因子：
11
作者：
Miller, S. L.;Fenstermacher, E.;Dickerson, B. C.
通讯作者：
Dickerson, B. C.
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
3.7
作者：
Bai F;Watson DR;Shi Y;Wang Y;Yue C;YuhuanTeng;Wu D;Yuan Y;Zhang Z
通讯作者：
Zhang Z
影响因子：
3.6
作者：
MCNEIL, BJ;HANLEY, JA
通讯作者：
HANLEY, JA
DOI：
10.1073/pnas.2235925100
发表时间：
2003-11-25
影响因子：
11.1
作者：
Lustig, C;Snyder, AZ;Buckner, RL
通讯作者：
Buckner, RL