Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment.
Specifically progressive deficits of brain functional marker in amnestic type mild cognitive impairment.
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DOI：
10.1371/journal.pone.0024271
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Bai F;Watson DR;Shi Y;Wang Y;Yue C;YuhuanTeng;Wu D;Yuan Y;Zhang Z
遗忘型轻度认知功能障碍（amnestic type mild cognitive impairment，aMCI）是阿尔茨海默病（Alzheimer's disease，AD）的高危人群，其默认模式网络（default mode network，DMN）存在缺陷。然而，没有纵向研究这个网络已报告在aMCI。确定DMN的发展和aMCI进展之间的联系将是相当大的价值，在了解大脑的变化支持aMCI和确定转换为AD的风险。在基线和大约20个月的随访后，在aMCI受试者（n = 26）和对照组（n = 18）中获得静息状态fMRI。 独立成分分析被用来隔离每个参与者的DMN。在基线时检查aMCI和对照组之间DMN的差异，并评估各组基线和随访之间的后续变化。在aMCI受试者中，在基线时观察到后扣带皮层/楔前叶（PCC/PCu）功能亢进连接，而与匹配的对照组相比，在aMCI受试者中，这些连接在随访时明显减少。具体而言，PCC/PCu功能障碍与aMCI组从基线到随访的情节记忆障碍呈正相关。DMN的纵向缺陷模式可能有助于研究者识别和监测aMCI的发展。
Deficits of the default mode network (DMN) have been demonstrated in subjects with amnestic type mild cognitive impairment (aMCI) who have a high risk of developing Alzheimer’s disease (AD). However, no longitudinal study of this network has been reported in aMCI. Identifying links between development of DMN and aMCI progression would be of considerable value in understanding brain changes underpinning aMCI and determining risk of conversion to AD. Resting-state fMRI was acquired in aMCI subjects (n = 26) and controls (n = 18) at baseline and after approximately 20 months follow up. Independent component analysis was used to isolate the DMN in each participant. Differences in DMN between aMCI and controls were examined at baseline, and subsequent changes between baseline and follow-up were also assessed in the groups. Posterior cingulate cortex/precuneus (PCC/PCu) hyper-functional connectivity was observed at baseline in aMCI subjects, while a substantial decrement of these connections was evident at follow-up in aMCI subjects, compared to matched controls. Specifically, PCC/PCu dysfunction was positively related to the impairments of episodic memory from baseline to follow up in aMCI group. The patterns of longitudinal deficits of DMN may assist investigators to identify and monitor the development of aMCI.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
10.6
作者：
Greicius, Michael D.;Flores, Benjamin H.;Schatzberg, Alan F.
通讯作者：
Schatzberg, Alan F.
影响因子：
2.5
作者：
Bai, Feng;Zhang, Zhijun;Qian, Yun
通讯作者：
Qian, Yun