Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection.
Protective human IgE responses are promoted by comparable life-cycle dependent Tegument Allergen-Like expression in Schistosoma haematobium and Schistosoma mansoni infection.
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DOI：
10.1371/journal.ppat.1011037
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发表时间：
2023-05
期刊：
影响因子：
6.7
通讯作者：
中科院分区：
文献类型：
--
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埃及血吸虫是最普遍的感染人类的寄生虫种，在地方性接触人群中造成严重发病。尽管如此，与它的同类S相比，它的研究相对不足。mansoni在这里，我们提供了第一个全面的表征的S。类过敏原蛋白家族是与沙门氏菌保护性免疫直接相关的关键蛋白家族。曼氏感染。与S. mansoni的系统发育分析和相关基因表达结合宿主血清学分析，支持S.在成虫死亡时暴露于宿主免疫系统的血吸虫TAL蛋白，以及在感染尾蚴和早期幼虫阶段的穿透过程中暴露的密切相关的蛋白。具体来说，我们的研究结果加强了由家族成员TAL3和TAL5之间的交叉反应性驱动的宿主免疫的证据，首次为S.血吸虫感染此外，我们建立在这种关系，包括TAL蛋白家族的一个额外的成员，TAL11的参与，为两个染色体物种。最后，我们显示了感染的经验和强度的传输和这些抗原的保护性IgE反应的发展之间的密切联系，从而提高我们的知识保护性宿主免疫反应的机制。这方面的知识将是至关重要的，了解控制工作，如大规模药物管理运动的影响，发展宿主免疫力和随后的模式感染和疾病的流行人群。S.埃及血吸虫是最普遍的感染人类的寄生虫。沿着S.曼索尼，它是负责大多数血吸虫病病例是由撒哈拉以南非洲，其中这种感染的全球负担是集中的人口承担。在这里，我们提供了对保护免受这些感染的IgE抗体反应的见解。通过计算机模拟分析结合免疫流行病学研究，我们探讨了宿主免疫保护和寄生虫蛋白家族命名为TegumentAllergen-Like（TAL）蛋白之间的关系。我们的研究结果表明，TAL蛋白家族的几个成员是重要的主机保护这两个主要的寄生虫物种。我们首次证明了针对S. haematobium，与之前在S.曼氏感染。我们还扩大了以前的知识为S。mansoni，鉴定TAL家族成员之间交叉反应关系的进一步复杂性，提供家族成员TAL 11在诱导保护性宿主免疫应答中的关键作用的证据。
Schistosoma haematobium is the most prevalent of the human-infecting schistosome species, causing significant morbidity in endemically exposed populations. Despite this, it has been relatively understudied compared to its fellow species, S. mansoni. Here we provide the first comprehensive characterization of the S. haematobium Tegument Allergen-Like protein family, a key protein family directly linked to protective immunity in S. mansoni infection. Comparable with observations for S. mansoni, parasite phylogenetic analysis and relative gene expression combined with host serological analysis support a cross-reactive relationship between S. haematobium TAL proteins, exposed to the host immune system as adult worms die, and closely related proteins, exposed during penetration by the infecting cercarial and early schistosomulae stages. Specifically, our results strengthen the evidence for host immunity driven by cross-reactivity between family members TAL3 and TAL5, establishing it for the first time for S. haematobium infection. Furthermore, we build upon this relationship to include the involvement of an additional member of the TAL protein family, TAL11 for both schistosome species. Finally, we show a close association between experience of infection and intensity of transmission and the development of protective IgE responses to these antigens, thus improving our knowledge of the mechanisms by which protective host immune responses develop. This knowledge will be critical in understanding how control efforts such as mass drug administration campaigns influence the development of host immunity and subsequent patterns of infection and disease within endemic populations. S. haematobium is the most prevalent of the human infecting schistosomes. Along with S. mansoni, it is responsible for the majority of schistosomiasis cases that are borne by the populations of sub-Saharan Africa, where the global burden of this infection is centered. Here, we provide insight into the IgE antibody response that protects against these infections. Through utilization of in silico analysis in combination with immuno-epidemiological studies, we explore the relationship between host immune protection and a parasite protein family named the Tegument Allergen-Like (TAL) proteins. Our results show that several members of the TAL protein family are important in host protection to both these major schistosome species. For the first time we demonstrate that a progressive cross-reactive TAL-IgE response occurs against S. haematobium, similar to that previous observed in S. mansoni infection. We additionally expand upon previous knowledge for S. mansoni, identifying further complexity in the cross-reactive relationship between TAL family members, providing evidence of a key role for family member TAL11 in induction of the protective host immune response.
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DOI：
10.1093/bioinformatics/8.3.275
发表时间：
1992-06-01
期刊：
COMPUTER APPLICATIONS IN THE BIOSCIENCES
影响因子：
--
作者：
JONES, DT;TAYLOR, WR;THORNTON, JM
通讯作者：
THORNTON, JM
影响因子：
10.7
作者：
Castresana, J
通讯作者：
Castresana, J
影响因子：
3.8
作者：
Asuming-Brempong EK;Ayi I;van der Puije W;Gyan BA;Larbi IA;Ashong Y;Frempong NA;Quartey JK;Otchere J;Jones FM;Wilson S;Dunne DW;Boakye DA
通讯作者：
Boakye DA
影响因子：
3.8
作者：
Chalmers IW;Fitzsimmons CM;Brown M;Pierrot C;Jones FM;Wawrzyniak JM;Fernandez-Fuentes N;Tukahebwa EM;Dunne DW;Khalife J;Hoffmann KF
通讯作者：
Hoffmann KF
影响因子：
4
作者：
Farias, Leonardo P.;Chalmers, Lain W.;Hoffmann, Karl F.
通讯作者：
Hoffmann, Karl F.