Prospective Longitudinal Characterization of the Relationship between Diabetes and Cardiac Structural and Functional Changes.
Prospective Longitudinal Characterization of the Relationship between Diabetes and Cardiac Structural and Functional Changes.
复制标题
糖尿病与心脏结构和功能变化之间关系的前瞻性纵向表征。
DOI：
10.1155/2022/6401180
复制
发表时间：
2022
影响因子：
2.1
通讯作者：
Levelt E
中科院分区：
文献类型：
--
作者：
Chowdhary A;Jex N;Thirunavukarasu S;MacCannell A;Haywood N;Almutairi A;Athithan L;Jain M;Craven T;Das A;Sharrack N;Saunderson CED;Sengupta A;Roberts L;Swoboda P;Cubbon R;Witte K;Greenwood J;Plein S;Levelt E
在接受基线心脏磁共振（CMR）和生物标志物检测的2型糖尿病（T2 D）患者队列中，在中位随访6年期间，我们旨在确定糖尿病心脏病表型表达的纵向变化，报告临床结局，并比较发生主要心血管不良事件（MACE）患者的基线临床特征和CMR结果那些没有发生MACE的人 2型糖尿病会增加心力衰竭（HF）和心血管死亡率的风险。在无心血管疾病和其他临床事件的情况下，T2 D对心脏表型的长期影响尚不清楚。 在基线时招募无心血管疾病或高血压病史的T2 D患者（n = 100）。通过CMR评估双心室容积、功能和心肌细胞外容积分数（ECV），并采集血液生物标志物。在6年后没有中期临床事件的患者中重复随访CMR。 83名参与者随访成功。其中，29例发生心血管/临床事件（36%）。在其余59例患者中，32例未发生事件的患者接受了随访CMR。在这个队列中，尽管血压、体重或糖化血红蛋白没有显著变化，但随着时间的推移，双心室舒张末期容积和射血分数显著降低。平均ECV不变。基线血浆高敏心肌肌钙蛋白T（hs-cTnT）与左心室（LV）射血分数的变化显著相关。与未发生严重不良心脏事件的患者相比，发生严重不良心脏事件的患者的左心室质量更高，左心室同心度更大。 即使在没有心血管/临床事件的情况下，T2 D也会导致双心室尺寸和收缩功能随时间推移而减小。
In a cohort of type 2 diabetic (T2D) patients who underwent baseline cardiac magnetic resonance (CMR) and biomarker testing, during a median follow-up of 6 years, we aimed to determine longitudinal changes in the phenotypic expression of heart disease in diabetes, report clinical outcomes, and compare baseline clinical characteristics and CMR findings of patients who experienced major adverse cardiovascular events (MACE) to those remaining MACE free. T2D increases the risk of heart failure (HF) and cardiovascular mortality. The long-term impact of T2D on cardiac phenotype in the absence of cardiovascular disease and other clinical events is unknown. Patients with T2D (n = 100) with no history of cardiovascular disease or hypertension were recruited at baseline. Biventricular volumes, function, and myocardial extracellular volume fraction (ECV) were assessed by CMR, and blood biomarkers were taken. Follow-up CMR was repeated in those without interim clinical events after 6 years. Follow-up was successful in 83 participants. Of those, 29 experienced cardiovascular/clinical events (36%). Of the remaining 59, 32 patients who experienced no events received follow-up CMR. In this cohort, despite no significant changes in blood pressure, weight, or glycated hemoglobin, significant reductions in biventricular end-diastolic volumes and ejection fractions occurred over time. The mean ECV was unchanged. Baseline plasma high-sensitivity cardiac troponin T (hs-cTnT) was significantly associated with a change in left ventricular (LV) ejection fraction. Patients who experienced MACE had higher LV mass and greater LV concentricity than those who remained event free. T2D results in reductions in biventricular size and systolic function over time even in the absence of cardiovascular/clinical events.
登录
查看更多内容
影响因子：
5.4
作者：
Swoboda PP;McDiarmid AK;Erhayiem B;Ripley DP;Dobson LE;Garg P;Musa TA;Witte KK;Kearney MT;Barth JH;Ajjan R;Greenwood JP;Plein S
通讯作者：
Plein S
在没有缺血性心脏病的2型糖尿病患者中存在左心室质量指数增加。
影响因子：
4.6
作者：
Seferovic JP;Tesic M;Seferovic PM;Lalic K;Jotic A;Biering-Sørensen T;Giga V;Stankovic S;Milic N;Lukic L;Milicic T;Macesic M;Gajovic JS;Lalic NM
通讯作者：
Lalic NM
影响因子：
7.7
作者：
Levelt E;Mahmod M;Piechnik SK;Ariga R;Francis JM;Rodgers CT;Clarke WT;Sabharwal N;Schneider JE;Karamitsos TD;Clarke K;Rider OJ;Neubauer S
通讯作者：
Neubauer S
影响因子：
37.8
作者：
Jia, Xiaoming;Sun, Wensheng;Ballantyne, Christie M.
通讯作者：
Ballantyne, Christie M.
影响因子：
7.7
作者：
Gulsin, Gaurav S.;Swarbrick, Daniel J.;McCann, Gerry P.
通讯作者：
McCann, Gerry P.