Of mice and men: the benefits of caloric restriction, exercise, and mimetics.
Of mice and men: the benefits of caloric restriction, exercise, and mimetics.
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DOI：
10.1016/j.arr.2011.11.005
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发表时间：
2012-07
影响因子：
13.1
通讯作者：
de Cabo, Rafael
中科院分区：
文献类型：
--
作者：
Mercken, Evi M.;Carboneau, Bethany A.;Krzysik-Walker, Susan M.;de Cabo, Rafael
在衰老过程中，能量摄入和消耗越来越不平衡，导致肥胖、虚弱和代谢紊乱。几十年来，研究表明热量限制（CR）和锻炼可以延缓衰老的不利方面。这两种干预措施引发了类似的生理特征，涉及与应激反应和线粒体稳态相关的途径。尽管如此，CR 能够延缓衰老过程，从而延长平均寿命和最长寿命，而运动主要是延长健康寿命。由于实现 CR 有益效果所需的严格饮食制度，迄今为止大多数研究都集中在啮齿动物和非人类灵长类动物上。因此，人们对开发白藜芦醇、二甲双胍和雷帕霉素等化合物产生了浓厚的兴趣，这些化合物可以激活由这些干预措施诱导的相同代谢和应激反应途径，而实际上不会限制热量摄入。因此，本次综述的范围是（i）描述 CR 和运动对健康个体的益处，（ii）讨论这些干预措施在疾病状态下的作用，以及（iii）研究一些有前途的药物替代方案，例如 CR 和运动模拟药物。
During aging there is an increasing imbalance of energy intake and expenditure resulting in obesity, frailty, and metabolic disorders. For decades, research has shown that caloric restriction (CR) and exercise can postpone detrimental aspects of aging. These two interventions invoke a similar physiological signature involving pathways associated with stress responses and mitochondrial homeostasis. Nonetheless, CR is able to delay aging processes that result in an increase of both mean and maximum lifespan, whereas exercise primarily increases healthspan. Due to the strict dietary regime necessary to achieve the beneficial effects of CR, most studies to date have focused on rodents and non-human primates. As a consequence, there is vast interest in the development of compounds such as resveratrol, metformin and rapamycin that would activate the same metabolic- and stress-response pathways induced by these interventions without actually restricting caloric intake. Therefore the scope of this review is to (i) describe the benefits of CR and exercise in healthy individuals, (ii) discuss the role of these interventions in the diseased state, and (iii) examine some of the promising pharmacological alternatives such as CR- and exercise-mimetics.
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DOI：
10.18632/aging.100273
发表时间：
2011-02
期刊：
Aging
影响因子：
--
作者：
Anisimov VN;Berstein LM;Popovich IG;Zabezhinski MA;Egormin PA;Piskunova TS;Semenchenko AV;Tyndyk ML;Yurova MN;Kovalenko IG;Poroshina TE
通讯作者：
Poroshina TE
DOI：
10.1126/science.1173635
发表时间：
2009-07-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Colman RJ;Anderson RM;Johnson SC;Kastman EK;Kosmatka KJ;Beasley TM;Allison DB;Cruzen C;Simmons HA;Kemnitz JW;Weindruch R
通讯作者：
Weindruch R
影响因子：
3
作者：
Beher, Dirk;Wu, John;Wang, Minghan
通讯作者：
Wang, Minghan
DOI：
10.1073/pnas.0403493101
发表时间：
2004-08-31
影响因子：
11.1
作者：
Bauer, JH;Goupil, S;Helfand, SL
通讯作者：
Helfand, SL
影响因子：
3.9
作者：
Anisimov, VN;Berstein, LM;Franceschi, C
通讯作者：
Franceschi, C