Computer modeling of the optical properties and heating of spherical gold and silica-gold nanoparticles for laser combined imaging and photothermal treatment
Computer modeling of the optical properties and heating of spherical gold and silica-gold nanoparticles for laser combined imaging and photothermal treatment
复制标题
用于激光组合成像和光热处理的球形金和硅金纳米颗粒的光学特性和加热的计算机建模
作者：
V. Pustovalov;L. Astafyeva;B. Jean
最近，几组研究人员（安德森、哈拉斯、扎罗夫、埃尔-赛义德和他们的同事（Pitsillides等2003 Biophys. J. 84 4023-31，Zharov等2003 Appl. Phys. Lett. 83 4897-9，Zharov等人2004 Proc. SPIE 5319 291-9，Loo等人2005 Nano Lett. 5 709-11，Gobin等人2007 Nano Lett. 7 1929-34，Fu等人2008 Nanotechnology 19 045103，Huang等人2006 J. Am. 128 2115-20，Jain等2006 J. Phys. Chem. B 110 7238-48，Jain等2007 Nano Today 2 18-29））通过开创性的结果证明了与金纳米颗粒缀合的细胞和组织的激光热疗法的巨大潜力。还提出了在纳米颗粒选择的基础上使用组合的诊断和治疗，以实现激光成像应用以及光热治疗的有效对比度。然而，目前对纳米颗粒的光学性质（吸收、背散射）、纳米颗粒加热的效率以及将它们用于组合成像和治疗的可能性之间的关系的理解是有限的。在这里，我们报告的结果的光学吸收和后向散射特性和激光加热的金和硅-金球形纳米粒子的激光结合成像和光热治疗的细胞和组织共轭纳米粒子的计算机建模。纳米粒子的加热和背散射的效率，取决于它们的半径，结构和金属的光学性质，进行了研究。本文主要研究了激光联合成像和光热处理中纳米颗粒尺寸的合理范围。研究了在确定的半径范围内使用球形金和二氧化硅-金纳米颗粒用于激光波长532和800 nm的这些目的的可能性。
Recently, several groups of investigators (Anderson, Halas, Zharov, El-Sayed and their co-workers (Pitsillides et al 2003 Biophys. J. 84 4023–31, Zharov et al 2003 Appl. Phys. Lett. 83 4897–9, Zharov et al 2004 Proc. SPIE 5319 291–9, Loo et al 2005 Nano Lett. 5 709–11, Gobin et al 2007 Nano Lett. 7 1929–34, Fu et al 2008 Nanotechnology 19 045103, Huang et al 2006 J. Am. Chem. Soc. 128 2115–20, Jain et al 2006 J. Phys. Chem. B 110 7238–48, Jain et al 2007 Nano Today 2 18–29)) demonstrated, through pioneering results, the great potential of laser thermal therapy of cells and tissues conjugated with gold nanoparticles. It was also proposed to use combined diagnostics and therapy on the basis of nanoparticle selection for achievement of efficient contrast for laser imaging applications, as well as for photothermal therapy. However, the current understanding of the relationship between optical properties (absorption, backscattering) of nanoparticles, the efficiency of nanoparticle heating and the possibility to use them for combined imaging and therapy is limited. Here, we report the results of computer modeling of optical absorption and backscattering properties and laser heating of gold and silica-gold spherical nanoparticles for laser combined imaging and photothermal treatment of cells and tissues conjugated with nanoparticles. The efficiencies of nanoparticle heating and backscattering by nanoparticles, depending upon their radii, structure and optical properties of the metal, were investigated. This paper focuses on the analysis and determination of appropriate ranges of nanoparticle sizes for the purposes of laser combined imaging and photothermal treatment. The possibility to use spherical gold and silica-gold nanoparticles in determined ranges of radii for these purposes for laser wavelengths 532 and 800 nm is investigated.
影响因子：
10.8
作者：
Gobin, Andre M.;Lee, Min Ho;West, Jennifer L.
通讯作者：
West, Jennifer L.