Enterotypes in the landscape of gut microbial community composition.

Enterotypes in the landscape of gut microbial community composition.
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DOI:
10.1038/s41564-017-0072-8
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发表时间:
2018-01
影响因子:
28.3
通讯作者:
Bork P
Bork P
中科院分区:
生物学1区
文献类型:
--
作者:
Costea PI;Hildebrand F;Arumugam M;Bäckhed F;Blaser MJ;Bushman FD;de Vos WM;Ehrlich SD;Fraser CM;Hattori M;Huttenhower C;Jeffery IB;Knights D;Lewis JD;Ley RE;Ochman H;O'Toole PW;Quince C;Relman DA;Shanahan F;Sunagawa S;Wang J;Weinstock GM;Wu GD;Zeller G;Zhao L;Raes J;Knight R;Bork P

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人口分层是更好地理解人类健康和福祉中复杂的生物学问题的有用方法。这种分层适用于人类肠道微生物组的提议,以不同的群落组成类型(称为“肠型”)的形式出现,引起了兴奋和争议。鉴于自原始工作以来积累的数据和重新分析,我们重新审视了肠型概念,讨论了划分可能的微生物组配置景观的不同方法,并将这些概念置于功能、生态和医学背景中。由于肠型可用于描述肠道微生物群落景观,并且可能与临床实践相关,因此我们的目标是调和不同的观点并鼓励平衡地应用该概念。
Population stratification is a useful approach towards a better understanding of complex biological problems in human health and well-being. The proposal that such stratification applies to the human gut microbiome, in the form of distinct community composition types, termed “enterotypes”, was met with both excitement and controversy. In view of accumulated data and re-analyses since the original work, we revisit the enterotype concept, discuss different methods of dividing up the landscape of possible microbiome configurations, and put these concepts into a functional, ecological and medical context. As enterotypes are of use in describing the gut microbial community landscape and may become relevant in clinical practice, we aim to reconcile differing views and encourage a balanced application of the concept.
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