A hyaluronic acid-binding contact lens with enhanced water retention.
A hyaluronic acid-binding contact lens with enhanced water retention.
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DOI：
10.1016/j.clae.2014.09.002
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发表时间：
2015-04
期刊：
影响因子：
--
通讯作者：
Elisseeff JH
中科院分区：
文献类型：
--
作者：
Singh A;Li P;Beachley V;McDonnell P;Elisseeff JH
Aa a main component of an artificial tear or eyedrop, hyaluronic acid (HA) prolongs water retention, slows tear removal, improves tear film stability, reduces protein adsorption at the ocular surface and permits uninterrupted blinking. Here, we hypothesized that the contact lens modified with an HA-binding peptide (HABpep) could locally bind and concentrate exogenous HA present in eyedrops to the modified contact lens surface, which exhibited superior water retention. To bind HA, a contact lens surface was covalently modified by HABpep with and without a poly(ethylene glycol) (PEG) spacer. Bound HA and its retention over time on the modified surfaces were evaluated by fluorescence measurements. A comparative water evaporation study was performed to determine water retention in an HA-bound contact lens. Fluorescence studies showed that the contact lens was successfully modified by HABpep with or without a PEG spacer, and HA bound to the contact lens surface. Furthermore, the bound HA via HABpep significantly reduced water loss from the modified contact lens. HABpep strategies that locally bind and concentrate HA to create a thin coating of a therapeutic molecule on surfaces could provide physical and biological benefits to treat ocular surface dysfunction. The surface bound HA via HABpep enhanced water retention in the modified contact lens.
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影响因子：
4.1
作者：
Mochizuki, H.;Yamada, M.;Nishida, T.
通讯作者：
Nishida, T.
DOI：
10.1084/jem.192.6.769
发表时间：
2000-09-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Mummert ME;Mohamadzadeh M;Mummert DI;Mizumoto N;Takashima A
通讯作者：
Takashima A
影响因子：
14
作者：
Nicolson, PC;Vogt, J
通讯作者：
Vogt, J
影响因子：
4.1
作者：
Condon, PI;McEwen, CG;McDonald, C
通讯作者：
McDonald, C
影响因子：
1.4
作者：
Papas, Eric B.;Tilia, Daniel;Golebiowski, Blanka
通讯作者：
Golebiowski, Blanka