Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains.
Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains.
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DOI：
10.1093/nar/gks1266
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发表时间：
2013-01
影响因子：
14.9
通讯作者：
Orengo C
中科院分区：
文献类型：
--
作者：
Lewis TE;Sillitoe I;Andreeva A;Blundell TL;Buchan DW;Chothia C;Cuff A;Dana JM;Filippis I;Gough J;Hunter S;Jones DT;Kelley LA;Kleywegt GJ;Minneci F;Mitchell A;Murzin AG;Ochoa-Montaño B;Rackham OJ;Smith J;Sternberg MJ;Velankar S;Yeats C;Orengo C
Genome 3D是一个新的合作项目，它整合了英国的结构资源，为序列-结构-功能关系提供了独特的视角。http://www.genome3d.eu领先的结构预测资源（DomSerf、Fugue、Gene 3D、pDomTHREADER、Phyre和SUPERFAMILY）为UniProt序列提供注释，以指示结构域的位置（结构注释）及其3D结构（结构模型）。结构注释和3D模型预测目前可用于三个模型基因组（智人，E.大肠杆菌和面包酵母），该项目将在不久的将来扩展到其他基因组。由于这些资源利用不同的策略来预测结构，Genome 3D的主要目标是实现所有资源之间的比较，以便生物学家可以看到预测的一致性，从而更加可信。此外，由于这些方法的不同之处在于它们是使用CATH还是SCOP建立预测，Genome 3D还包含这两个数据库之间的第一个官方映射。这已经从两个资源中以不同程度的共识确定了相似的超家族对（532对青铜对，527对银对和370对黄金对）。
Genome3D, available at http://www.genome3d.eu, is a new collaborative project that integrates UK-based structural resources to provide a unique perspective on sequence–structure–function relationships. Leading structure prediction resources (DomSerf, FUGUE, Gene3D, pDomTHREADER, Phyre and SUPERFAMILY) provide annotations for UniProt sequences to indicate the locations of structural domains (structural annotations) and their 3D structures (structural models). Structural annotations and 3D model predictions are currently available for three model genomes (Homo sapiens, E. coli and baker’s yeast), and the project will extend to other genomes in the near future. As these resources exploit different strategies for predicting structures, the main aim of Genome3D is to enable comparisons between all the resources so that biologists can see where predictions agree and are therefore more trusted. Furthermore, as these methods differ in whether they build their predictions using CATH or SCOP, Genome3D also contains the first official mapping between these two databases. This has identified pairs of similar superfamilies from the two resources at various degrees of consensus (532 bronze pairs, 527 silver pairs and 370 gold pairs).
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影响因子：
14.9
作者：
Lees J;Yeats C;Redfern O;Clegg A;Orengo C
通讯作者：
Orengo C
影响因子：
14.9
作者：
Gough, J;Chothia, C
通讯作者：
Chothia, C
影响因子：
5.6
作者：
TAYLOR, WR;ORENGO, CA
通讯作者：
ORENGO, CA
影响因子：
14.9
作者：
de Lima Morais DA;Fang H;Rackham OJ;Wilson D;Pethica R;Chothia C;Gough J
通讯作者：
Gough J
影响因子：
14.9
作者：
Gough J
通讯作者：
Gough J