Virology under the Microscope-a Call for Rational Discourse.
Virology under the Microscope-a Call for Rational Discourse.
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作者：
病毒给人类带来了许多挑战：呼吸道感染、癌症、神经损伤和免疫抑制，仅举几例。过去60多年的病毒学研究已经通过疫苗和抗病毒药来减轻这种疾病的负担。尽管历史悠久，但COVID-19大流行为病毒学领域带来了前所未有的关注。其中一些注意力集中在对人类病原体研究的安全进行的关注上。一小群人抓住了这些担忧--将安全进行病毒相关研究的合法问题与SARS-CoV-2起源的不确定性混为一谈。结果引发了公众的困惑，在许多情况下，对病毒学的谴责是不明智的。通过这篇文章，我们试图促进理性话语的回归。我们解释了在科学中使用的功能获得的方法，讨论了可能的起源SARS-CoV-2和概述目前的监管结构，在美国提供病毒学研究的监督。通过提供我们的专业知识，我们-一个广泛的工作病毒学家小组-寻求帮助政策制定者在导航这些有争议的问题。平衡的、以证据为基础的话语对于解决公众关注的问题，同时保持和扩大急需的病毒学研究至关重要。
Viruses have brought humanity many challenges: respiratory infection, cancer, neurological impairment and immunosuppression to name a few. Virology research over the last 60+ years has responded to reduce this disease burden with vaccines and antivirals. Despite this long history, the COVID-19 pandemic has brought unprecedented attention to the field of virology. Some of this attention is focused on concern about the safe conduct of research with human pathogens. A small but vocal group of individuals has seized upon these concerns – conflating legitimate questions about safely conducting virus-related research with uncertainties over the origins of SARS-CoV-2. The result has fueled public confusion and, in many instances, ill-informed condemnation of virology. With this article, we seek to promote a return to rational discourse. We explain the use of gain-of-function approaches in science, discuss the possible origins of SARS-CoV-2 and outline current regulatory structures that provide oversight for virological research in the United States. By offering our expertise, we – a broad group of working virologists – seek to aid policy makers in navigating these controversial issues. Balanced, evidence-based discourse is essential to addressing public concern while maintaining and expanding much-needed research in virology.
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影响因子：
46.9
作者：
通讯作者：
--
影响因子：
82.9
作者：
Menachery VD;Yount BL Jr;Debbink K;Agnihothram S;Gralinski LE;Plante JA;Graham RL;Scobey T;Ge XY;Donaldson EF;Randell SH;Lanzavecchia A;Marasco WA;Shi ZL;Baric RS
通讯作者：
Baric RS
DOI：
10.1073/pnas.2214427119
发表时间：
2022-11-22
影响因子：
11.1
作者：
Garry, Robert F.
通讯作者：
Garry, Robert F.
DOI：
10.1073/pnas.191389398
发表时间：
2001-09-25
影响因子：
11.1
作者：
Gaxiola, RA;Li, JS;Fink, GR
通讯作者：
Fink, GR
影响因子：
5.9
作者：
Loke, Desmond K.;Clausen, Griffin J.;Belcher, Angela M.
通讯作者：
Belcher, Angela M.