A study of granulated metrial gland cells in the pregnant, alymphoplasia (aly/aly) mice.
A study of granulated metrial gland cells in the pregnant, alymphoplasia (aly/aly) mice.
复制标题
对怀孕的发育不全 (aly/aly) 小鼠的粒状子宫腺细胞的研究。
DOI：
--
复制
发表时间：
1997
影响因子：
1.2
通讯作者：
F. Sasaki
中科院分区：
文献类型：
--
作者：
Y. Kiso;K. Kusakabe;Y. Tokunaga;M. Makita;T. Okada;F. Sasaki
妊娠期间，子宫NK细胞（通常称为颗粒状子宫腺（GMG）细胞）在免疫活性小鼠和各种免疫缺陷小鼠的子宫中分化。控制GMG细胞分化的调节机制尚不完全清楚。已经证明GMG细胞来源于骨髓，在孕酮和雌激素的影响下出现，不需要胚胎的存在，并且在啮齿动物中与子宫基质的蜕膜化相关。基因型aly/aly的小鼠由于淋巴相关的间充质疾病而在淋巴结和派尔集合淋巴结中遗传缺陷。它们被认为是研究淋巴细胞和基质成分之间相互作用的有用模型。这种免疫缺陷动物与在怀孕期间分化GMG细胞的nu/nu和scid/scid小鼠完全不同。为了确定GMG细胞的分化是否依赖于子宫中的间充质相互作用，在妊娠第10天和第14天之间对aly/aly小鼠的GMG细胞分化和子宫腺发育进行了组织学研究。在aly/aly小鼠中存在子宫腺组织，并且表现正常。与对照妊娠aly/+小鼠相比，GMG细胞的分布无显著差异。在妊娠第12天和第14天，aly/aly小鼠中的GMG细胞少于aly/+小鼠。妊娠第10天和第12天的GMG细胞个体特征不同。aly/aly小鼠的GMG细胞体积小，颗粒发育不良。然而，到第14天，GMG细胞获得了成熟的大小，颗粒似乎成熟。妊娠aly/aly小鼠的GMG细胞分化可能延迟，这是由于间充质疾病影响该动物的子宫腺发育。
During pregnancy, a population of uterine NK cells, commonly called granulated metrial gland (GMG) cells, differentiates in the uterus of both immune competent and various immunodeficient mice. Regulatory mechanisms controlling the differentiation of GMG cells are not fully known. It has been proven that GMG cells are derived from bone marrow, appear under the influences of progesterone and estrogen, do not require the presence of an embryo, and are associated in rodents with decidualization of the uterine stroma. Mice of genotype aly/aly are genetically deficient in lymph nodes and Peyer's patches due to a lymphoid-associated mesenchymal disorder. They are considered to be a useful model for the study of interactions between lymphocytes and stromal components. This immunodeficient animal is completely different from nu/nu and scid/scid mice who differentiate GMG cells during pregnancy. To determine whether the differentiation of GMG cells depends on mesenchymal interactions in the uterus, aly/aly mice were studied histologically between days 10 and 14 of pregnancy for differentiation of GMG cells and development of the metrial gland. Metrial gland tissue was present and appeared normal in aly/aly mice. There were no significant differences in the distribution of GMG cells in comparison to control pregnant aly/+ mice. Fewer GMG cells were present in aly/aly mice than aly/+ mice on days 12 and 14 of pregnancy. The features of individual GMG cells were different on days 10 and 12 of pregnancy. GMG cells in aly/aly mice were small in size and the granules were poorly developed. By day 14, however, GMG cells acquired a mature size and the granules appeared mature. It is likely that GMG cell differentiation was delayed in pregnant aly/aly mice, due to a mesenchymal disorder affecting metrial gland development in this animal.
登录
查看更多内容
影响因子：
4.4
作者：
A. Hamann;D. Andrew;D. Jablonski‐Westrich;B. Holzmann;E. Butcher
通讯作者：
A. Hamann;D. Andrew;D. Jablonski‐Westrich;B. Holzmann;E. Butcher
怀孕小鼠子宫的粒状子宫腺细胞是含有穿孔素和丝氨酸酯酶的自然杀伤样细胞。
DOI：
--
发表时间：
1990
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Parr,EL;Young,LH;Parr,MB;Young,JD
通讯作者：
Young,JD
单克隆抗体 4H12 可识别来自怀孕和新生小鼠的粘附淋巴细胞因子激活的杀伤细胞和脾脏自然杀伤细胞的子集。
DOI：
--
发表时间：
1991
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Linnemeyer,PA;Pollack,SB
通讯作者：
Pollack,SB
小鼠颗粒状子宫腺细胞裂解 YAC 靶细胞的演示。
影响因子：
4.3
作者：
Croy,BA;Reed,N;Malashenko,BA;Kim,K;Kwon,BS
通讯作者：
Kwon,BS
影响因子：
15.9
作者：
DAMSKY, CH;FITZGERALD, ML;FISHER, SJ
通讯作者：
FISHER, SJ