Dosimetric evaluation of heterogeneity corrections for RTOG 0236: stereotactic body radiotherapy of inoperable stage I-II non-small-cell lung cancer.
Dosimetric evaluation of heterogeneity corrections for RTOG 0236: stereotactic body radiotherapy of inoperable stage I-II non-small-cell lung cancer.
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DOI：
10.1016/j.ijrobp.2008.11.019
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发表时间：
2009-03-15
影响因子：
7
通讯作者：
Galvin, James M.
中科院分区：
文献类型：
--
作者：
Xiao, Ying;Papiez, Lech;Paulus, Rebecca;Timmerman, Robert;Straube, William L.;Bosch, Wailter R.;Michalski, Jeff;Galvin, James M.
通过对多个机构向RTOG#0236非小细胞SBRT方案提交的治疗计划的回顾分析，本研究确定了未来SBRT肺方案的剂量处方和关键结构约束，这些约束要求进行密度校正剂量计算。比较了来自参与0236方案并使用叠加/卷积算法的四个机构的20名患者的子集。0236方案要求处方剂量为60GY，分三次给予，以覆盖95%的PTV体积。对目标剂量的异质性和对正常组织/结构的剂量规定了额外的要求。该方案要求每个地点使用单位密度来计划患者的治疗，并提交了另一个具有相同监测单元并应用密度校正的计划。对这些方案进行了比较，以确定剂量差异。采用双侧配对t检验来评估这些差异。应用异质性校正后，接受60GY或以上剂量(V60)的PTV体积从95%(P=0.001)平均减少10.1%(SE=2.7%)。距离PTV 2 cm或以上的最大剂量从35.2Gy1.7Gy.增加到38.5Gy2.2Gy.经异质性校正后，剂量差异有统计学意义。这项研究中提供的信息目前正用于设计未来异质性校正的RTOG SBRT肺部方案，以匹配0236的真实剂量。
Using a retrospective analysis of treatment plans submitted from multiple institutions accruing patients to the RTOG #0236 non-small cell SBRT protocol, this study determines the dose prescription and critical structure constraints for future SBRT lung protocols that mandate density corrected dose calculations. A subset of twenty patients from four institutions participating in the 0236 protocol and using superposition/convolution algorithms are compared. The 0236 protocol required a prescription dose of 60 Gy delivered in three fractions to cover 95% of the PTV volume. Additional requirements were specified for target dose heterogeneity and dose to normal tissue/structures. The protocol required each site to plan the patient’s treatment using unit density, and another plan with the same monitor units and applying density corrections was also submitted. These plans have been compared to determine dose differences. A two-sided paired student’s t-tests were used to evaluate these differences. With heterogeneity corrections applied, the volume of PTV receiving 60 Gy or more (V60) decreased on average 10.1% (SE=2.7%) from 95% (p=0.001). Maximum dose to any point 2 cm or greater away from the PTV increased from 35.2 Gy (SE =1.7 Gy) to 38.5 (SE=2.2 Gy). Statistically significant dose differences were found with heterogeneity corrections. The information provided in this study is currently being used for designing future heterogeneity corrected RTOG SBRT lung protocols to match the true dose delivered for 0236.
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影响因子：
3.5
作者：
Knoos, Tommy;Wieslander, Elinore;Lassen, Soren
通讯作者：
Lassen, Soren
影响因子：
3.5
作者：
Panettieri, Vanessa;Wennberg, Berit;Lax, Ingmar
通讯作者：
Lax, Ingmar
影响因子：
254.7
作者：
Jemal, A;Tiwari, RC;Thun, MJ
通讯作者：
Thun, MJ
DOI：
10.1016/0360-3016(92)91013-d
发表时间：
1992-01-01
影响因子：
7
作者：
DOSORETZ, DE;KATIN, MJ;METKE, MP
通讯作者：
METKE, MP
影响因子：
3.8
作者：
Ding, George X.;Duggan, Dennis M.;Coffey, Charles W.
通讯作者：
Coffey, Charles W.