Impact of SARS-CoV-2 Pandemic on Patients with Primary Immunodeficiency.
Impact of SARS-CoV-2 Pandemic on Patients with Primary Immunodeficiency.
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DOI：
10.1007/s10875-020-00928-x
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发表时间：
2021-03
影响因子：
9.1
通讯作者：
Aghamohamamdi A
中科院分区：
文献类型：
--
作者：
Delavari S;Abolhassani H;Abolnezhadian F;Babaha F;Iranparast S;Ahanchian H;Moazzen N;Nabavi M;Arshi S;Fallahpour M;Bemanian MH;Shokri S;Momen T;Sadeghi-Shabestari M;Molatefi R;Shirkani A;Vosughimotlagh A;Safarirad M;Sharifzadeh M;Pashangzadeh S;Salami F;Shirmast P;Rezaei A;Moeini Shad T;Mohraz M;Rezaei N;Hammarström L;Yazdani R;Aghamohamamdi A
尽管据估计，50岁以下的感染者中确诊的新冠肺炎危及生命的病例可能不到1：1000，但这场大流行对不同类型的原发免疫缺陷(PID)儿科患者的真正影响尚未阐明。目前对全国PID患者登记的前瞻性研究显示，这些患者的感染率仅高出1.23倍，与人群相比，死亡率高出10倍，主要是在合并免疫缺陷和免疫失调的患者中。因此，应考虑进一步针对新冠肺炎的治疗方式，以提高这两个实体的存活率，使用造血干细胞移植和免疫调节剂。网上版载有补充材料，可在10.1007/s10875-020-00928-x查阅。
Although it is estimated that COVID-19 life-threatening conditions may be diagnosed in less than 1:1000 infected individuals below the age of 50, but the real impact of this pandemic on pediatric patients with different types of primary immunodeficiency (PID) is not elucidated. The current prospective study on a national registry of PID patients showed that with only 1.23 folds higher incidence of infections, these patients present a 10-folds higher mortality rate compared to population mainly in patients with combined immunodeficiency and immune dysregulation. Therefore, further management modalities against COVID-19 should be considered to improve the survival rate in these two PID entities using hematopoietic stem cell transplantation and immunomodulatory agents. The online version contains supplementary material available at 10.1007/s10875-020-00928-x.
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