Dopaminergic activation of estrogen receptors induces fos expression within restricted regions of the neonatal female rat brain.
Dopaminergic activation of estrogen receptors induces fos expression within restricted regions of the neonatal female rat brain.
复制标题
雌激素受体的多巴胺能激活在新生儿大鼠脑的受限区域内诱导FOS表达。
DOI：
10.1371/journal.pone.0002177
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发表时间：
2008-05-14
期刊：
影响因子：
3.7
通讯作者：
Auger, Anthony P.
中科院分区：
文献类型：
--
作者：
Olesen, Kristin M.;Auger, Anthony P.
Steroid receptor activation in the developing brain influences a variety of cellular processes that endure into adulthood, altering both behavior and physiology. Recent data suggests that dopamine can regulate expression of progestin receptors within restricted regions of the developing rat brain by activating estrogen receptors in a ligand-independent manner. It is unclear whether changes in neuronal activity induced by dopaminergic activation of estrogen receptors are also region specific. To investigate this question, we examined where the dopamine D1-like receptor agonist, SKF 38393, altered Fos expression via estrogen receptor activation. We report that dopamine D1-like receptor agonist treatment increased Fos protein expression within many regions of the developing female rat brain. More importantly, prior treatment with an estrogen receptor antagonist partially reduced D1-like receptor agonist-induced Fos expression only within the bed nucleus of the stria terminalis and the central amygdala. These data suggest that dopaminergic activation of estrogen receptors alters neuronal activity within restricted regions of the developing rat brain. This implies that ligand-independent activation of estrogen receptors by dopamine might organize a unique set of behaviors during brain development in contrast to the more wide spread ligand activation of estrogen receptors by estrogen.
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影响因子：
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通讯作者：
KATZENELLENBOGEN, BS
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