Part 2: Quantitative proton T2 and sodium magnetic resonance imaging to assess intervertebral disc degeneration in a rabbit model.
Part 2: Quantitative proton T2 and sodium magnetic resonance imaging to assess intervertebral disc degeneration in a rabbit model.
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DOI：
10.1097/brs.0b013e3182583447
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发表时间：
2012-08-15
期刊：
影响因子：
3
通讯作者：
Bae KT
中科院分区：
文献类型：
--
作者：
Moon CH;Jacobs L;Kim JH;Sowa G;Vo N;Kang J;Bae KT
兔正常椎间盘与退变椎间盘钠浓度[23Na]及质子T2弛豫时间的比较本文的目的是评估与退行性变相关的椎间盘的定量[23Na]和T2特征。椎间盘退变（IDD）是一种常见的慢性疾病，可导致背部疼痛、活动受限和残疾。早期IDD的无创影像检测对跟踪疾病进展、指导临床治疗和管理具有重要意义。使用3T对兔椎间盘进行双调谐（DT） MRI。研究中包括13只兔子；对照组6只（正常椎间盘24只），环刺性椎间盘退变兔7只（退变椎间盘9只，完整内控椎间盘19只）。在基线和穿刺后12周对椎间盘进行DT MRI检查。测量三组椎间盘的[23Na]和T2并进行比较。正常椎间盘的平均[23Na]为274.8±40.2 mM，内控椎间盘为247.2±27.7 mM，退变椎间盘为190.6±19.1 mM。三组相应的T2分别为：97.1±12.1 ms、93.7±11.9 ms、79.0±9.1 ms。[23Na]与退变椎间盘内T2高度相关（r = 0.90, P < 0.01）。从正常到退变椎间盘的平均下降百分比在[23Na]为30.6%，在T2为18.6%，而从内控到退变椎间盘的平均下降百分比在[23Na]为22.9%，在T2为15.6%。虽然椎间盘[23Na]和T2的变化与椎间盘穿刺兔有关，但与T2变化相比，刺伤后12周观察到[23Na]的变化更大。由于T2和[23Na]反映的椎间盘性质不同，在相同条件下进行两种成像有助于椎间盘退变的评估。
Comparison of sodium concentration ([23Na]) and proton T2 relaxation time between normal and degenerated discs in a rabbit model. The purpose of this article is to evaluate quantitative [23Na] and T2 characteristics of discs associated with degenerative changes. Intervertebral disc degeneration (IDD) is a common chronic condition that may lead to back pain, limited activity, and disability. Non-invasive imaging method to detect early IDD is vital to follow disease progression and guide clinical treatment and management. Dual-tuned (DT) MRI of rabbit discs was performed using a 3T. Thirteen rabbits were included in the study; six control rabbits (24 normal discs) and seven rabbits with annular-puncture-induced disc degeneration (9 degenerated discs, 19 intact internal-control discs). DT MRI of discs were performed at baseline and 12-week post-stab. [23Na] and T2 were measured and compared among three groups of discs. The mean [23Na] were 274.8 ± 40.2 mM for the normal discs, 247.2 ± 27.7 mM for the internal-control discs, and 190.6 ± 19.1 mM for the degenerated discs. The corresponding T2 for three groups were: 97.1 ± 12.1 ms, 93.7 ± 11.9 ms, and 79.0 ± 9.1 ms, respectively. The [23Na] is highly correlated with the T2 in the degenerated discs (r = 0.90, P < 0.01). The mean percent decrease from the normal to degenerated discs were in 30.6% in [23Na] and 18.6% in T2, while those from the internal-control to degenerated discs were 22.9% in [23Na] and 15.6% in T2. While both [23Na] and T2 changes in discs were associated with the disc-punctured rabbits, greater change in [23Na] is observed at 12-week post-stab compared to T2 change. Since T2 and [23Na] reflect different disc properties, performing both imaging under same condition will be helpful in the evaluation of disc degeneration.
影响因子：
3.3
作者：
McCommis, Kyle S.;Koktzoglou, Ioannis;Zhang, Haosen;Goldstein, Thomas A.;Northrup, Benjamin E.;Li, Debiao;Gropler, Robert J.;Zheng, Jie
通讯作者：
Zheng, Jie