Improvement of hyperemic myocardial oxygen extraction fraction estimation by a diffusion-prepared sequence.
Improvement of hyperemic myocardial oxygen extraction fraction estimation by a diffusion-prepared sequence.
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DOI：
10.1002/mrm.22427
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发表时间：
2010-06
影响因子：
3.3
通讯作者：
Zheng, Jie
中科院分区：
文献类型：
--
作者：
McCommis, Kyle S.;Koktzoglou, Ioannis;Zhang, Haosen;Goldstein, Thomas A.;Northrup, Benjamin E.;Li, Debiao;Gropler, Robert J.;Zheng, Jie
充血时心肌氧摄取分数（OEF）可使用双反转恢复（DIF）准备的T2加权黑血序列来估计。由于心率升高和/或心律失常导致的严重不规则ECG触发可能导致难以充分抑制流动的左心室血液信号，从而可能导致心肌OEF估计的错误。因此，本研究的目的是评价另一种黑血技术，弥散加权（DW）准备TSE序列确定充血期间局部心肌OEF的能力。对照犬和急性冠状动脉狭窄的犬在休息时和潘生丁或多巴酚丁胺充血期间均使用经皮和DW制备的TSE序列进行成像。使用对照犬动脉和冠状窦的血液采样进行MRI OEF估计值的验证。两种方法与血液采样结果的相关性相当（R2 = 0.9）。除多巴酚丁胺应激期间冠状动脉严重狭窄的犬组外，所有犬的OEF估计值相似。在这些犬中，DW方法提供的OEF（充血OEF = 0.75 ± 0.08，静息OEF为0.6）在生理学上更合理（充血OEF = 0.56 ± 0.10）。DW准备可能是一种有价值的替代方法，可在不规则ECG触发期间进行更准确的氧合测量。
Myocardial oxygen extraction fraction (OEF) during hyperemia can be estimated using a double-inversion-recovery (DIR) prepared T2-weighted black-blood sequence. Severe irregular ECG-triggering due to elevated heart rate and/or arrhythmias may render it difficult to adequately suppress the flowing left ventricle blood signal and thus potentially cause errors in the estimates of myocardial OEF. Thus, the goal of this study was to evaluate another black-blood technique, a diffusion-weighted (DW)-prepared TSE sequence for its ability to determine regional myocardial OEF during hyperemia. Control dogs and dogs with acute coronary artery stenosis were imaged with both the DIR- and DW-prepared TSE sequences at rest and during either dipyridamole or dobutamine hyperemia. Validation of MRI OEF estimates was performed using blood sampling from the artery and coronary sinus in control dogs. The two methods showed comparable correlations with blood sampling results (R2 = 0.9). Similar OEF estimations for all dogs were observed except for the group of dogs with severe coronary stenosis during dobutamine stress. In these dogs, the DW method provided more physiologically reasonable OEF (hyperemic OEF = 0.75 ± 0.08 vs resting OEF of 0.6) than the DIR method (hyperemic OEF = 0.56 ± 0.10). DW-preparation may be a valuable alternative for more accurate oxygenation measurements during irregular ECG-triggering.
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
4.4
作者：
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通讯作者：
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