Cannabis containing equivalent concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) induces less state anxiety than THC-dominant cannabis.
Cannabis containing equivalent concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) induces less state anxiety than THC-dominant cannabis.
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DOI：
10.1007/s00213-022-06248-9
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发表时间：
2022-11
影响因子：
3.4
通讯作者：
Ramaekers, J. G.
中科院分区：
文献类型：
--
作者：
Hutten, Nadia R. P. W.;Arkell, T. R.;Vinckenbosch, F.;Schepers, J.;Kevin, R. C.;Theunissen, E. L.;Kuypers, K. P. C.;McGregor, I. S.;Ramaekers, J. G.
三角洲-9-四氢大麻酚(THC)是大麻的一种活性成分，在醉酒期间会导致一些使用者的焦虑。大麻二酚(CBD)是大麻的另一种成分，具有抗焦虑特性，这表明除了THC外，含有CBD的大麻产品可能比只含THC的产品产生的焦虑更少。到目前为止，围绕这个问题的发现还没有定论，可以想象，这可能取决于缓和因素，如用户的基线焦虑水平。本研究调查了单剂蒸发的THC、CBD和THC/CBD后的焦虑是否可以用基线时的状态和特质焦虑水平来解释。一项包括26名健康的娱乐性大麻使用者的安慰剂对照、随机、受试者内研究测试了蒸发THC主导大麻(13.75毫克THC)、CBD主导大麻(13.75毫克CBD)、相当于THC/CBD的大麻(13.75毫克THC/13.75毫克CBD)和安慰剂大麻对焦虑的影响。采用状态-特质焦虑量表(STAI)评定自测特质焦虑。焦虑状态用计算机情绪Stroop任务(EST)客观评定，用STAI-状态问卷和视觉模拟量表主观评定。与安慰剂相比，THC和THC/CBD都显著增加了自我评估的状态焦虑。THC/CBD组状态焦虑显著低于单纯THC组。在基线水平上，THC诱导的焦虑与焦虑无关。当基线焦虑较低时，CBD完全抵消THC诱导的焦虑；而当基线焦虑较高时，CBD不能抵消THC诱导的焦虑。任何治疗条件对EST均无影响。总体而言，研究表明，与THC/CBD相当的大麻比以THC为主的大麻引起的状态焦虑更少。网上版载有补充材料，可在10.1007/s00213-022-06248-9查阅。
Delta-9-tetrahydrocannabinol (THC), an active component of cannabis, can cause anxiety in some users during intoxication. Cannabidiol (CBD), another constituent of cannabis, has anxiolytic properties suggesting that cannabis products containing CBD in addition to THC may produce less anxiety than THC-only products. Findings to date around this issue have been inconclusive and could conceivably depend on moderating factors such as baseline anxiety levels in users. The present study examined whether anxiety following single doses of vaporised THC, CBD and THC/CBD might be explained by state and trait anxiety levels at baseline. A placebo-controlled, randomised, within-subjects study including 26 healthy recreational cannabis users tested the effects of vaporised THC-dominant cannabis (13.75 mg THC), CBD-dominant cannabis (13.75 mg CBD), THC/CBD-equivalent cannabis (13.75 mg THC/13.75 mg CBD) and placebo cannabis on anxiety. Self-rated trait anxiety was assessed with the State-Trait Anxiety Inventory (STAI). State levels of anxiety were objectively assessed with a computer-based emotional Stroop task (EST) and subjectively rated with the STAI-state questionnaire and a visual analogue scale. Both THC and THC/CBD significantly increased self-rated state anxiety compared to placebo. State anxiety after THC/CBD was significantly lower than after THC alone. THC-induced anxiety was independent of anxiety at baseline. When baseline anxiety was low, CBD completely counteracted THC-induced anxiety; however, when baseline anxiety was high, CBD did not counteract THC-induced anxiety. There were no effects of any treatment condition on the EST. Overall, the study demonstrated that the THC/CBD-equivalent cannabis induces less state anxiety than THC-dominant cannabis. The online version contains supplementary material available at 10.1007/s00213-022-06248-9.
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