Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series.
Acute liver injury due to flavocoxid (Limbrel), a medical food for osteoarthritis: a case series.
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DOI：
10.7326/0003-4819-156-12-201206190-00006
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发表时间：
2012-06-19
影响因子：
39.2
通讯作者：
Hoofnagle JH
中科院分区：
文献类型：
--
作者：
Chalasani N;Vuppalanchi R;Navarro V;Fontana R;Bonkovsky H;Barnhart H;Kleiner DE;Hoofnagle JH
Flavocoxid是一种医疗食品，可用于骨关节炎的饮食管理处方。它是两种黄酮类化合物，黄芩苷和儿茶素的专有混合物，分别来自植物学黄芩和儿茶。描述疑似由黄酮类药物引起的急性肝损伤患者的特征。药物性肝损伤网络（DILIN）的病例系列前瞻性研究于2004年在多个学术医疗中心启动。4例患者疑似因flavocoxid导致肝损伤。临床特征、肝脏生化、组织学和结局。在DILIN前瞻性研究中入组的877例患者中，4例归因于flavocoxid。所有4例均为女性，平均年龄为61岁。在开始使用flavocoxid治疗后，至发作的时间平均为11.2周（范围为5-16周）。肝损伤的特征为丙氨酸氨基转移酶显著升高（平均峰值ALT 1268 U/L，范围741 - 1540 U/L），碱性磷酸酶中度升高（平均峰值510 U/L，范围286 - 770 U/L）和血清胆红素中度升高（平均峰值9.4 mg/dL，范围2.0 - 20.8 mg/dL）。停药后3 ~ 12周，肝脏生化指标均恢复正常。3例患者的因果关系被裁定为很可能相关，1例患者的因果关系被裁定为可能相关。所有患者均顺利恢复，无急性肝衰竭或慢性肝损伤迹象。无法评估flavocoxid引起肝损伤的频率或机制。Flavocoxid可引起严重的肝损伤，似乎在其停止后几周内消退。
Flavocoxid is a medical food that is available with prescription for dietary management of osteoarthritis. It is a proprietary blend of two flavonoids, baicalin and catechins which are derived from botanicals Scutellaria baicalensis and Acacia catechu respectively. To describe characteristics of patients with acute liver injury suspected due to flavocoxid. Case series Prospective Study of the Drug Induced Liver Injury Network (DILIN) initiated at multiple academic medical centers in 2004. 4 patients with liver injury suspected due to flavocoxid. Clinical characteristics, liver biochemistries, histology, and outcomes. Among 877 patients enrolled in the DILIN Prospective Study, 4 were attributed to flavocoxid. All 4 were women with a mean age of 61 years. The time to onset averaged 11.2 weeks (range 5–16) after initiating therapy with flavocoxid. Liver injury was characterized by marked elevations in alanine aminotransferase (mean peak ALT 1268 U/L, range 741 to 1540 U/L), with moderate elevations in alkaline phosphatase (mean peak 510 U/L, range 286 to 770 U/L) and serum bilirubin (mean peak 9.4 mg/dL, range 2.0 to 20.8 mg/dL). Liver biochemistries fell into the normal range within 3 to 12 weeks of stopping. The causality was adjudicated as highly likely in three and as possible in one patient. All recovered uneventfully with no evidence acute liver failure or chronic liver injury. The frequency or mechanism of liver injury caused by flavocoxid cannot be assessed. Flavocoxid can cause significant liver injury which appears to resolve within weeks after its cessation.
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长期服用黄芩苷可改善高脂饮食大鼠的代谢紊乱和肝脂肪变性
影响因子：
8.2
作者：
Guo, Hong-xia;Liu, Dai-hua;Peng, Hong-li
通讯作者：
Peng, Hong-li
影响因子：
4.2
作者：
Fontana RJ;Watkins PB;Bonkovsky HL;Chalasani N;Davern T;Serrano J;Rochon J;DILIN Study Group
通讯作者：
DILIN Study Group
影响因子：
2.3
作者：
Pillai, Lakshmi;Burnett, Bruce P.;Levy, Robert M.
通讯作者：
Levy, Robert M.
影响因子：
29.4
作者：
Davern TJ;Chalasani N;Fontana RJ;Hayashi PH;Protiva P;Kleiner DE;Engle RE;Nguyen H;Emerson SU;Purcell RH;Tillmann HL;Gu J;Serrano J;Hoofnagle JH;Drug-Induced Liver Injury Network (DILIN)
通讯作者：
Drug-Induced Liver Injury Network (DILIN)
影响因子：
13.5
作者：
Rockey, Don C.;Seeff, Leonard B.;Rochon, James;Freston, James;Chalasani, Naga;Bonacini, Maurizio;Fontana, Robert J.;Hayashi, Paul H.
通讯作者：
Hayashi, Paul H.